TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

[Des-octanoyl]-Ghrelin functions as a ligand for an alternative, high-affinity receptor distinct from the canonical Growth Hormone Secretagogue Receptor 1a (GHSR1a). Unlike acylated ghrelin, it does not activate GHSR1a, which mediates growth hormone release and orexigenic effects. Instead, it is believed to bind to a specific, yet not fully characterized, "unacylated ghrelin receptor" or modulate receptor complexes involving GHSR1a, triggering unique intracellular signaling cascades.

2.PRODUCT INDICATIONS

Control in Ghrelin Studies: Serving as an essential negative control in experiments to differentiate the specific effects mediated by GHSR1a activation (via acylated ghrelin) from those mediated by alternative receptors or non-specific mechanisms.
Metabolic Research: Investigating its unique role in glucose homeostasis, insulin sensitivity, and lipid metabolism in rat models of diabetes or obesity.
Cardiovascular Physiology: Studying its potential protective effects on the heart (e.g., ischemia-reperfusion injury) and vasculature in preclinical rat models.
Non-Canonical Signaling Studies: Exploring its distinct signaling pathways in tissues where its effects oppose those of acylated ghrelin, such as in adipocytes or pancreatic cells.
Receptor Pharmacology: Aiding in the identification and characterization of the putative high-affinity receptor for unacylated ghrelin.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical Evidence in Rodents: Studies in rats demonstrate that unacylated ghrelin has biological activity, influencing metabolic parameters and exerting cardioprotective effects, despite being devoid of GH-releasing or appetite-stimulating activity.

Human Relevance & Therapeutic Potential: Research in humans indicates that circulating unacylated ghrelin has beneficial metabolic effects, such as improving insulin sensitivity and beta-cell survival. It is being investigated as a potential therapeutic candidate for metabolic syndrome and cardiovascular diseases due to its favorable profile (e.g., no stimulation of appetite).
Current Status: The rat peptide itself is not a clinical drug. Its use is confined to preclinical research that validates the target and biological effects, which may inform the development of human therapeutics based on the unacylated ghrelin molecule or mimetics.



4.DELIVERY & SHIPPING


We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods 
Main Method: International Air Freight


We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.