[Des-Thr7]-Glucagon CAS NO.1802078-28-9

[Des-Thr7]-Glucagon (CAS No.: 1802078-28-9) is a synthetic glucagon analog with the molecular formula C₁₄₉H₂₁₈N₄₂O₄₇S and a molecular weight of 3381.72 g/mol. Engineered for superior purity (>95% by RP-HPLC) and biological stability, this peptide is a critical tool for metabolic research, diabetes drug development, and glucagon receptor pathway studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	GLP-1 (7-36)-Lys(biotinyl) amide (human, bovine, guinea pig, mouse, rat)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C165H252N44O48S
Molecular Weight	3652.18 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥ 5 mg/mL), dilute acetic acid, DMSO, and phosphate-buffered saline (PBS)
Endotoxin	≤1.0 EU/mg
Biological Activity	Retains native GLP-1 receptor agonist activity; EC₅₀ typically ≤ 0.3 nM in cAMP accumulation assays; biotin label enables detection via streptavidin conjugates.
Storage Conditions	Store at -20°C to -80°C in a dry, dark, desiccated environment.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Stimulation of glycogenolysis and gluconeogenesis in liver cells to elevate blood glucose levels.

Promotion of lipolysis in adipose tissue for energy mobilization.

Inhibition of gastric acid secretion and motility via indirect neural pathways.

Research applications: Diabetes therapeutics, metabolic syndrome modeling, and obesity drug discovery.

2.PRODUCT INDICATIONS

Diabetes mellitus type 1/2: Evaluates glucagon counter-regulatory responses.

Metabolic disorders: Investigates dysregulated glucose/lipid metabolism.

Obesity pharmacology: Assesses anti-obesity therapies inhibiting GCGR activity.

Endocrine research: Examines glucagon’s role in energy homeostasis.

3.CLINICAL EFFICACY OF PRODUCT

Glucose Regulation: Demonstrates >80% efficacy in restoring normoglycemia in diabetic murine models within 60 minutes post-administration.

Receptor Binding Affinity: EC₅₀ = 0.3 nM for human GCGR (comparable to native glucagon).

Stability: Maintains >90% bioactivity after 48 hours at 4°C in PBS buffer.

4.DELIVERY & SHIPPING

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