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[Des-Thr7]-Glucagon CAS NO.1802078-28-9

[Des-Thr7]-Glucagon CAS NO.1802078-28-9

[Des-Thr7]-Glucagon CAS NO.1802078-28-9
[Des-Thr7]-Glucagon CAS NO.1802078-28-9

[Des-Thr7]-Glucagon CAS NO.1802078-28-9

[Des-Thr7]-Glucagon CAS NO.1802078-28-9

[Des-Thr7]-Glucagon (CAS No.: 1802078-28-9) is a synthetic glucagon analog with the molecular formula C₁₄₉H₂₁₈N₄₂O₄₇S and a molecular weight of 3381.72 g/mol. Engineered for superior purity (>95% by RP-HPLC) and biological stability, this peptide is a critical tool for metabolic research, diabetes drug development, and glucagon receptor pathway studies.

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TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
GLP-1 (7-36)-Lys(biotinyl) amide (human, bovine, guinea pig, mouse, rat)
CAS NO.
/
Appearance
White to off-white lyophilized powder
Molecular Formula
C165H252N44O48S
Molecular Weight
3652.18 g/mol
Purity (RP-HPLC)
≥ 95.0%
Solubility

Soluble in water (≥ 5 mg/mL), dilute acetic acid, DMSO, and phosphate-buffered saline (PBS)

Endotoxin≤1.0 EU/mg
Biological Activity
Retains native GLP-1 receptor agonist activity; EC₅₀ typically ≤ 0.3 nM in cAMP accumulation assays; biotin label enables detection via streptavidin conjugates.
Storage Conditions
Store at -20°C to -80°C in a dry, dark, desiccated environment.
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

Stimulation of glycogenolysis and gluconeogenesis in liver cells to elevate blood glucose levels.

Promotion of lipolysis in adipose tissue for energy mobilization.
Inhibition of gastric acid secretion and motility via indirect neural pathways.
Research applications: Diabetes therapeutics, metabolic syndrome modeling, and obesity drug discovery.

    2.PRODUCT INDICATIONS

    Diabetes mellitus type 1/2: Evaluates glucagon counter-regulatory responses.

    Metabolic disorders: Investigates dysregulated glucose/lipid metabolism.

    Obesity pharmacology: Assesses anti-obesity therapies inhibiting GCGR activity.

    Endocrine research: Examines glucagon’s role in energy homeostasis.

    3.CLINICAL EFFICACY OF PRODUCT

    Glucose Regulation: Demonstrates >80% efficacy in restoring normoglycemia in diabetic murine models within 60 minutes post-administration.
    Receptor Binding Affinity: EC₅₀ = 0.3 nM for human GCGR (comparable to native glucagon).
    Stability: Maintains >90% bioactivity after 48 hours at 4°C in PBS buffer.


    4.DELIVERY & SHIPPING

    We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
    Professional and Secure Packaging
    Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
    We can also customize packaging according to customer needs.
    Shipping Methods 
    Main Method: International Air Freight

    We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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