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Renoguanylin (eel)

Renoguanylin (eel) is a high-purity synthetic peptide derived from the Japanese eel (Anguilla japonica), representing a member of the guanylin peptide family. This species-specific peptide is primarily expressed in the kidney and plays a crucial role in osmoregulation and ion transport in fish. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this product provides researchers with a specialized tool for studying comparative endocrinology, fish physiology, and the evolutionary aspects of guanylate cyclase-C (GC-C) receptor signaling. With validated structural integrity and potential biological activity, Renoguanylin enables investigations into piscine osmoregulatory mechanisms, renal function, and environmental adaptation in aquatic species.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Renoguanylin (eel)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C66H102N16O22S4
Molecular Weight	1599.9g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid, PBS (pH 7-8)
Endotoxin	< 1.0 EU/mg
Biological Activity	Eel kidney guanosine peptide; belonging to the guanosine peptide family, it can activate guanylate cyclase receptors and participate in osmotic pressure regulation and ion balance. It is a tool peptide for studying osmotic regulation and kidney function in fish.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Renoguanylin (eel) functions as an endogenous ligand that binds to and activates guanylate cyclase-C (GC-C) receptors in fish tissues, particularly in the kidney and intestine. This binding stimulates the intracellular catalytic domain of GC-C, leading to the conversion of GTP to cyclic GMP (cGMP). The elevated cGMP levels activate downstream effectors, including protein kinase G (PKG), which phosphorylates ion channels and transporters involved in electrolyte transport. In eels and other teleost fish, this signaling cascade primarily regulates sodium and chloride ion transport across epithelial membranes, contributing to osmoregulation in both freshwater and marine environments. The peptide's activity is dependent on proper disulfide bond formation, which maintains its three-dimensional structure and receptor-binding affinity.

2.PRODUCT INDICATIONS

Comparative Endocrinology Research: Investigation of guanylin peptide family evolution and species-specific differences

Fish Physiology Studies: Evaluation of osmoregulatory mechanisms in teleost fish

Renal Function Research: Assessment of kidney function and ion transport in aquatic species

Environmental Adaptation Studies: Investigation of how fish adapt to different salinity conditions

GC-C Receptor Signaling: Characterization of guanylate cyclase-C activation in non-mammalian systems

Evolutionary Biology: Comparative analysis of guanylin peptide systems across vertebrate species

3.CLINICAL EFFICACY OF PRODUCT

Structural Integrity: Verified disulfide bond formation (if applicable for the specific sequence)

Sequence Accuracy: Verified amino acid sequence corresponding to eel Renoguanylin

Research Reproducibility: Consistent performance in functional assays across multiple batches

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for comparative physiology research

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.