Tyr-Uroguanylin (rat)

Tyr-Uroguanylin (rat) is a high-purity synthetic peptide representing an N-terminal tyrosine-modified form of rat uroguanylin. This 16-amino acid peptide retains the biological activity of native uroguanylin while incorporating a tyrosine residue at the N-terminus, which facilitates radiolabeling, detection, and enhanced solubility properties. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this product provides researchers with a versatile tool for studying guanylate cyclase-C (GC-C) receptor signaling, gastrointestinal physiology, and renal function. The tyrosine modification enables applications in receptor binding assays, competitive inhibition studies, and detection-based experiments, making it particularly valuable for quantitative and analytical research approaches.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Tyr-Uroguanylin (rat)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C69H105N17O27S4
Molecular Weight	1732.96g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid, PBS (pH 7-8)
Endotoxin	< 1.0 EU/mg
Biological Activity	The N-terminal tyrosine-modified form of rat uroguanylin; a guanylate cyclase-C (GC-C) receptor agonist involved in intestinal fluid secretion, electrolyte balance, and renal function regulation.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Tyr-Uroguanylin (rat) functions as a guanylate cyclase-C (GC-C) receptor agonist, binding to the extracellular domain of GC-C receptors expressed on intestinal and renal epithelial cells. This binding activates the intracellular catalytic domain, leading to the conversion of GTP to cyclic GMP (cGMP). The elevated intracellular cGMP levels activate protein kinase G (PKG), which phosphorylates downstream effectors including the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. This signaling cascade stimulates chloride and bicarbonate secretion while inhibiting sodium absorption, ultimately regulating fluid and electrolyte transport. The N-terminal tyrosine modification does not significantly alter the peptide's receptor-binding affinity or biological activity, allowing it to function similarly to native uroguanylin while providing additional utility for detection and labeling applications.

2.PRODUCT INDICATIONS

GC-C Receptor Signaling: Investigation of guanylate cyclase-C activation and downstream pathways

Gastrointestinal Physiology: Evaluation of intestinal fluid secretion and electrolyte transport mechanisms

Renal Function Research: Assessment of kidney function and ion transport regulation

Detection-Based Applications: Use in ELISA, Western blot, or other immunoassays due to tyrosine modification

Competitive Inhibition Studies: Evaluation of GC-C receptor antagonists or competing ligands

Receptor Binding Assays: Radiolabeling with iodine-125 for competitive binding studies and receptor characterization

3.CLINICAL EFFICACY OF PRODUCT

Structural Integrity: Verified disulfide bond formation (Cys-Cys pairs) essential for biological activity

Sequence Accuracy: Verified 16-amino acid sequence with confirmed N-terminal tyrosine modification

Biological Activity: Validated in cell-based assays measuring cGMP production or chloride secretion

Research Reproducibility: Consistent performance in functional assays across multiple batches

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for receptor binding and detection assays

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.