[Des-Gly10,Dleu6, ProNHEt9] LH-RH, AcetateLeuprolide, Acetate CAS NO.74381-53-6

A synthetic peptide analog of gonadotropin-releasing hormone (GnRH), Leuprolide Acetate suppresses gonadotropin secretion via receptor desensitization, used in hormone-sensitive cancers and reproductive disorders.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Des-Gly10,Dleu6, ProNHEt9] LH-RH, Acetate / Leuprolide, Acetate
CAS NO.	74381-53-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C₅₉H₈₄N₁₆O₁₂·C₂H₄O₂
Molecular Weight	1269.45g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	It is soluble in common organic solvents such as dimethyl sulfoxide (DMSO) and slightly soluble in water.
Endotoxin	< 1.0 EU/mg
Biological Activity	[Des-Gly10,Dleu6, ProNHEt9] LH – RH, Acetate / Leuprolide, Acetate is a potent agonist of the LH – RH receptor. It binds to the receptor with high affinity, leading to the down – regulation of gonadotropin secretion.
Storage Conditions	The product should be stored at – 20°C in a dry and dark environment.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GnRH Receptor Agonist: Binds pituitary GnRH receptors, initially stimulating LH/FSH release.

Downregulation: Prolonged binding inhibits gonadotropin synthesis, reducing testosterone/estrogen levels.

Hormonal Suppression: Clinically effective for prostate cancer, endometriosis, and precocious puberty.

2.PRODUCT INDICATIONS

Oncology: Metastatic prostate cancer, breast cancer (hormone receptor-positive).

Reproductive Health: Endometriosis, uterine fibroids, precocious puberty.

Assisted Reproduction: Ovulation induction in IVF protocols.

3.CLINICAL EFFICACY OF PRODUCT

Prostate Cancer: Reduces testosterone to castration levels (~90% efficacy).

Endometriosis: 70-90% symptom relief in 6 months.

Pediatrics: Normalizes growth in central precocious puberty.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
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Shipping Methods
Main Method: International Air Freight

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