[Gln8] LH-RH, chicken CAS NO.47922-48-5

[Gln8] LH-RH, chicken (CAS NO.: 47922-48-5) is a synthetic analog of luteinizing hormone-releasing hormone (LH-RH) designed for reproductive biology research. With the molecular formula C₆₀H₈₉N₁₅O₁₄ and a molecular weight of 1332.50 g/mol, this high-purity peptide (>95% HPLC) exhibits potent bioactivity in modulating gonadotropin release. Ideal for laboratory investigations into endocrine pathways and ovulation induction, it is available for global research institutions.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Gln8] LH – RH, chicken
CAS NO.	47922 – 48 – 5
Appearance	White to off-white lyophilized powder
Molecular Formula	C₅₄H₇₁N₁₅O₁₄
Molecular Weight	1154.28g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water or aqueous buffers.
Endotoxin	< 1.0 EU/mg
Biological Activity	In bioassays, it has been demonstrated to have a significant impact on the regulation of reproductive hormones. When tested in vitro using pituitary cell cultures, it can stimulate the release of luteinizing hormone (LH) and follicle – stimulating hormone (FSH).
Storage Conditions	Store at -20°C, protected from light.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Receptor Binding: Selectively binds to gonadotropin-releasing hormone receptors (GnRHRs) on pituitary gonadotrophs.

Signal Transduction: Activates intracellular PLC/IP₃/Ca²⁺ pathways, triggering exocytosis of LH and FSH.

Hormonal Regulation: Induces pulsatile release of LH/FSH, critical for ovulation and gonadal steroidogenesis.

Desensitization: Prolonged exposure may cause transient receptor downregulation, reducing efficacy at high doses.

2.PRODUCT INDICATIONS

Research Applications: Studies on hypothalamic-pituitary-gonadal (HPG) axis dysfunction.

Reproductive Biology: Investigation of ovulation induction mechanisms in avian and mammalian models.

Drug Development: Preclinical screening of GnRH-based therapeutics for infertility or endocrine disorders.

Endocrinology: Assessment of LH/FSH secretion dynamics under physiological or pathological conditions.

3.CLINICAL EFFICACY OF PRODUCT

In Vitro: Stimulates LH/FSH release from rat pituitary cells with EC₅₀ values<1 nm="">

In Vivo: Induces ovulation in chicken models within 6–12 hours post-administration (5–10 μg/kg SC).

Therapeutic Potential: Shown to restore gonadotropin levels in GnRH-deficient rodent models.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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