Name: Gln8 LH-RH Chicken Peptide – High-Purity for Reproductive Use
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[Gln8] LH-RH, chicken CAS NO.47922-48-5

[Gln8] LH-RH, chicken (CAS NO.: 47922-48-5) is a synthetic analog of luteinizing hormone-releasing hormone (LH-RH) designed for reproductive biology research. With the molecular formula C₆₀H₈₉N₁₅O₁₄ and a molecular weight of 1332.50 g/mol, this high-purity peptide (>95% HPLC) exhibits potent bioactivity in modulating gonadotropin release. Ideal for laboratory investigations into endocrine pathways and ovulation induction, it is available for global research institutions.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Gln8] LH - RH, chicken
CAS NO.	47922 - 48 - 5
Appearance	White to off-white lyophilized powder
Molecular Formula	C₅₄H₇₁N₁₅O₁₄
Molecular Weight	1154.28g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water or aqueous buffers.
Endotoxin	< 1.0 EU/mg
Biological Activity	In bioassays, it has been demonstrated to have a significant impact on the regulation of reproductive hormones. When tested in vitro using pituitary cell cultures, it can stimulate the release of luteinizing hormone (LH) and follicle - stimulating hormone (FSH).
Storage Conditions	Store at -20°C, protected from light.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Receptor Binding: Selectively binds to gonadotropin-releasing hormone receptors (GnRHRs) on pituitary gonadotrophs.

Signal Transduction: Activates intracellular PLC/IP₃/Ca²⁺ pathways, triggering exocytosis of LH and FSH.

Hormonal Regulation: Induces pulsatile release of LH/FSH, critical for ovulation and gonadal steroidogenesis.

Desensitization: Prolonged exposure may cause transient receptor downregulation, reducing efficacy at high doses.

2.PRODUCT INDICATIONS

Research Applications: Studies on hypothalamic-pituitary-gonadal (HPG) axis dysfunction.

Reproductive Biology: Investigation of ovulation induction mechanisms in avian and mammalian models.

Drug Development: Preclinical screening of GnRH-based therapeutics for infertility or endocrine disorders.

Endocrinology: Assessment of LH/FSH secretion dynamics under physiological or pathological conditions.

3.CLINICAL EFFICACY OF PRODUCT

In Vitro: Stimulates LH/FSH release from rat pituitary cells with EC₅₀ values<1 nm="">

In Vivo: Induces ovulation in chicken models within 6–12 hours post-administration (5–10 μg/kg SC).

Therapeutic Potential: Shown to restore gonadotropin levels in GnRH-deficient rodent models.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.