MAGE-3 Antigen (271-279), human CAS NO.160295-81-8

MAGE-3 Antigen (271-279), human is a synthetic peptide corresponding to residues 271–279 of the human melanoma-associated antigen MAGE-3. This high-purity antigen is designed for research and diagnostic applications, particularly in immunology and cancer studies. It serves as a critical tool for T-cell stimulation, epitope mapping, and the development of targeted cancer immunotherapies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	MAGE-3 Antigen (271-279), human
CAS NO.	160295-81-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C53H79N13O10
Molecular Weight	1058.3g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, 0.1 M acetic acid, or DMSO at a concentration of ≥ 1 mg/mL
Endotoxin	< 1.0 EU/mg
Biological Activity	Recognized by HLA-A2-restricted cytotoxic T lymphocytes (CTLs) specific for MAGE-3
Storage Conditions	Store at -20°C to -80°C for long-term storage; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide acts as a human leukocyte antigen (HLA)-restricted epitope, primarily presented by HLA-A2 molecules on antigen-presenting cells. Upon presentation, it activates cytotoxic T-lymphocytes (CTLs) specific to MAGE-3-expressing tumors, triggering an immune response aimed at eliminating malignant cells. This mechanism underpins its utility in studying T-cell recognition and antitumor immunity.

2.PRODUCT INDICATIONS

This antigen is indicated for use in scientific research, including in vitro T-cell activation assays, immunotherapy development, and immunological studies targeting melanoma and other MAGE-3-positive cancers. It is also employed in diagnostic reagent development and vaccine research to evaluate immune responses against tumor-associated antigens.

3.CLINICAL EFFICACY OF PRODUCT

While primarily for research use, studies demonstrate that MAGE-3-derived peptides can induce specific CTL responses in preclinical models, supporting their potential in adoptive cell therapies and cancer vaccine platforms. Clinical trials involving MAGE-3 antigens have shown promise in eliciting antitumor immunity, highlighting its relevance in advancing personalized cancer treatments.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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