Name: MAGE-3 Antigen (271-279) Human Peptide CAS 160295-81-8 Sample
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MAGE-3 Antigen (271-279), human CAS NO.160295-81-8

MAGE-3 Antigen (271-279), human is a synthetic peptide corresponding to residues 271–279 of the human melanoma-associated antigen MAGE-3. This high-purity antigen is designed for research and diagnostic applications, particularly in immunology and cancer studies. It serves as a critical tool for T-cell stimulation, epitope mapping, and the development of targeted cancer immunotherapies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	MAGE-3 Antigen (271-279), human
CAS NO.	160295-81-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C53H79N13O10
Molecular Weight	1058.3g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, 0.1 M acetic acid, or DMSO at a concentration of ≥ 1 mg/mL
Endotoxin	< 1.0 EU/mg
Biological Activity	Recognized by HLA-A2-restricted cytotoxic T lymphocytes (CTLs) specific for MAGE-3
Storage Conditions	Store at -20°C to -80°C for long-term storage; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide acts as a human leukocyte antigen (HLA)-restricted epitope, primarily presented by HLA-A2 molecules on antigen-presenting cells. Upon presentation, it activates cytotoxic T-lymphocytes (CTLs) specific to MAGE-3-expressing tumors, triggering an immune response aimed at eliminating malignant cells. This mechanism underpins its utility in studying T-cell recognition and antitumor immunity.

2.PRODUCT INDICATIONS

This antigen is indicated for use in scientific research, including in vitro T-cell activation assays, immunotherapy development, and immunological studies targeting melanoma and other MAGE-3-positive cancers. It is also employed in diagnostic reagent development and vaccine research to evaluate immune responses against tumor-associated antigens.

3.CLINICAL EFFICACY OF PRODUCT

While primarily for research use, studies demonstrate that MAGE-3-derived peptides can induce specific CTL responses in preclinical models, supporting their potential in adoptive cell therapies and cancer vaccine platforms. Clinical trials involving MAGE-3 antigens have shown promise in eliciting antitumor immunity, highlighting its relevance in advancing personalized cancer treatments.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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