Mastoparan 7 CAS NO.145854-59-7

Mastoparan 7 is a high-purity synthetic tetradecapeptide analog derived from wasp venom, characterized by its amphipathic α-helical structure and enhanced G-protein activating properties. This 14-amino acid peptide (typically INLKALAALAKKIL-NH₂ or similar modified sequence) is manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation. As an optimized derivative of natural mastoparan, Mastoparan 7 exhibits increased potency in G-protein activation while maintaining similar membrane-interacting properties. It serves as a valuable research tool for studying signal transduction pathways, membrane permeability, and comparative pharmacology of amphipathic peptides.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Mastoparan 7
CAS NO.	145854-59-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C67H124N18O15
Molecular Weight	1421.85g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS (pH 7‑8), DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Mastoparan analogues possess G protein activation, membrane permeability regulation, antibacterial, and secretion-promoting activities, and are used in signal transduction, cell biology, and drug research.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Mastoparan 7 functions through its amphipathic α-helical structure that enables direct interaction with G-protein α-subunits and cell membranes. Unlike receptor-mediated activation, Mastoparan 7 directly stimulates guanine nucleotide exchange on Gi/Go-type G-proteins by mimicking the intracellular loops of activated GPCRs, leading to GDP-GTP exchange and downstream signaling activation. The peptide's enhanced amphipathicity and cationic charge distribution compared to natural mastoparan result in higher affinity for G-protein binding sites. Additionally, Mastoparan 7 can interact with nucleoside diphosphate kinase (NDPK) to facilitate GTP formation, modulate membrane permeability through transient pore formation, and influence calcium signaling pathways. Its mechanism is characterized by receptor-independent, direct G-protein activation with increased efficacy in reconstituted systems.

2.PRODUCT INDICATIONS

G-Protein Signaling Research: Study of Gi/Go protein activation kinetics, GTPase activity, and signal transduction mechanisms

Comparative Pharmacology: Investigation of structure-activity relationships in mastoparan analogs and amphipathic peptides

Membrane Biology Studies: Analysis of peptide-membrane interactions, lipid bilayer permeability, and membrane protein function

Signal Transduction Screening: Evaluation of G-protein modulators and receptor-independent signaling pathways

Pharmacological Tool Development: Optimization of peptide-based research reagents for cell signaling studies

Antimicrobial Mechanism Research: Exploration of membrane-disrupting properties against microbial pathogens

3.CLINICAL EFFICACY OF PRODUCT

Enhanced Potency: Demonstrated 2-3 fold higher G-protein activating efficacy compared to natural mastoparan in reconstituted systems

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and C-terminal amidation

Sequence Authenticity: Verified modified mastoparan sequence with optimized amphipathic properties

Biological Activity: Validated in G-protein activation assays, GTPase activity measurements, and membrane interaction studies

Research Reproducibility: Consistent performance across multiple assay platforms and experimental conditions

Low Endotoxin:<1.0 eu="">

Quality Documentation: Certificate of Analysis provided with comprehensive analytical data including purity, mass spec, and functional validation

Technical Support: Access to application guidance for G-protein signaling and peptide pharmacology research

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.