Mas-ETH CAS NO.172519-53-8

Mas-ETH Peptide (CAS Number: 172519-53-8) is a high-purity research-grade G protein-coupled receptor agonist with a molecular formula of C₅₉H₈₅N₁₅O₁₃S and a molecular weight of 1252.48 g/mol. Manufactured to ≥98% purity (verified by RP-HPLC), this lyophilized peptide acts as a potent agonist for MRGPRX1 and related Mas-related receptors, serving as a critical tool for preclinical research in pain, inflammation, and pruritus pathways. With low endotoxin levels (≤1.0 EU/µg) and consistent batch-to-batch reproducibility, it meets the rigorous standards of academic and pharmaceutical research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Mas-ETH
CAS NO.	172519-53-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C127H206N36O38S3
Molecular Weight	2941.45g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥10 mg/mL), dilute acetic acid, or 0.01M PBS
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of MRGPRX1 and related Mas-related G protein-coupled receptors, mediating analgesic, anti-inflammatory, and pruritic effects by modulating peripheral sensory neuron signaling. Validated for pain and itch pathway research.
Storage Conditions	-20°C to -80°C in a desiccated environment, avoiding repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Mas-ETH Peptide exerts its biological activity through selective binding to MRGPRX1 (Mas-related G protein-coupled receptor X1), predominantly expressed on peripheral sensory neurons and immune cells. Upon receptor activation, it triggers intracellular signaling cascades (e.g., Ca²⁺ mobilization and MAPK pathway activation) that modulate two key biological responses: 1) Suppression of nociceptor excitability, leading to analgesic effects by reducing pain signal transmission to the central nervous system; 2) Inhibition of pro-inflammatory cytokine release (e.g., IL-1β, TNF-α) from immune cells, alleviating peripheral inflammation. Additionally, its interaction with MRGPRX1 mediates pruritic signaling, making it a valuable tool for studying itch pathways.

2.PRODUCT INDICATIONS

Insect Developmental Biology: Study the molecular regulation of molting and metamorphosis in Lepidoptera and other arthropods.

Neuroendocrinology: Investigate the interaction between hormonal signals and neural circuitry controlling behavior.

Agricultural Biotechnology: Serve as a reference standard for developing eco-friendly biopesticides that disrupt pest molting cycles.

Mode of Action Studies: Used in pharmacological assays to understand GPCR activation in invertebrates.

3.CLINICAL EFFICACY OF PRODUCT

Induce Pre-ecdysis Behavior within 2 to 10 minutes of administration in pharate larvae, pupae, or adults.

Trigger Complete Ecdysis sequences, mimicking natural hormonal release.

Demonstrate High Specificity with minimal off-target effects in isolated CNS preparations.

Maintain Stability under proper storage conditions, ensuring long-term experimental reliability.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.