Mas-ETH CAS NO.172519-53-8
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Mas-ETH |
| CAS NO. | 172519-53-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C127H206N36O38S3 |
| Molecular Weight | 2941.45g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥10 mg/mL), dilute acetic acid, or 0.01M PBS |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Potent agonist of MRGPRX1 and related Mas-related G protein-coupled receptors, mediating analgesic, anti-inflammatory, and pruritic effects by modulating peripheral sensory neuron signaling. Validated for pain and itch pathway research. |
| Storage Conditions | -20°C to -80°C in a desiccated environment, avoiding repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Mas-ETH Peptide exerts its biological activity through selective binding to MRGPRX1 (Mas-related G protein-coupled receptor X1), predominantly expressed on peripheral sensory neurons and immune cells. Upon receptor activation, it triggers intracellular signaling cascades (e.g., Ca²⁺ mobilization and MAPK pathway activation) that modulate two key biological responses: 1) Suppression of nociceptor excitability, leading to analgesic effects by reducing pain signal transmission to the central nervous system; 2) Inhibition of pro-inflammatory cytokine release (e.g., IL-1β, TNF-α) from immune cells, alleviating peripheral inflammation. Additionally, its interaction with MRGPRX1 mediates pruritic signaling, making it a valuable tool for studying itch pathways.
2.PRODUCT INDICATIONS
Insect Developmental Biology: Study the molecular regulation of molting and metamorphosis in Lepidoptera and other arthropods.
Neuroendocrinology: Investigate the interaction between hormonal signals and neural circuitry controlling behavior.
Agricultural Biotechnology: Serve as a reference standard for developing eco-friendly biopesticides that disrupt pest molting cycles.
Mode of Action Studies: Used in pharmacological assays to understand GPCR activation in invertebrates.
3.CLINICAL EFFICACY OF PRODUCT
Induce Pre-ecdysis Behavior within 2 to 10 minutes of administration in pharate larvae, pupae, or adults.
Trigger Complete Ecdysis sequences, mimicking natural hormonal release.
Demonstrate High Specificity with minimal off-target effects in isolated CNS preparations.
Maintain Stability under proper storage conditions, ensuring long-term experimental reliability.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
