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MBP (87-99), human; Myelin Basic Protein (87-99), guinea pig, human CAS NO.118506-26-6

MBP (87-99), human; Myelin Basic Protein (87-99), guinea pig, human is a high-purity synthetic peptide preparation containing two distinct but related sequences: the human and guinea pig variants of the MBP 87-99 encephalitogenic epitope. This product provides researchers with both species-specific sequences (VHFFKNIVTPRTP for human, VHFFKNIVTPHPQ for guinea pig) in a single preparation, enabling comparative studies of autoimmune epitope recognition and species-specific immune responses. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this dual-sequence product serves as a critical tool for experimental autoimmune encephalomyelitis (EAE) model development, T cell epitope mapping, and multiple sclerosis research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	MBP (87-99), human; Myelin Basic Protein (87-99), guinea pig, human
CAS NO.	118506-26-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C74H114N20O17
Molecular Weight	1555.86g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS (pH 7-8), or an aqueous solution containing a small amount of DMSO.
Endotoxin	< 1.0 EU/mg
Biological Activity	Autoimmune epitopes of myelin basic proteins; can induce experimental autoimmune encephalomyelitis (EAE), used for multiple sclerosis models, T-cell epitope and autoimmune research.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The MBP 87-99 peptide functions as a major encephalitogenic epitope that induces autoimmune responses through MHC class II presentation. Antigen-presenting cells (APCs) process and present the peptide via MHC class II molecules to CD4⁺ T helper cells. The specific interaction between the peptide-MHC complex and T cell receptors (TCRs) activates autoreactive T cells, leading to their proliferation and differentiation into Th1 or Th17 effector cells. These activated T cells migrate across the blood-brain barrier, recognize myelin basic protein in the central nervous system, and initiate an inflammatory cascade involving cytokine release, macrophage activation, and demyelination. The guinea pig sequence (VHFFKNIVTPHPQ) is particularly potent in inducing EAE in susceptible animal strains due to its high affinity for certain MHC class II molecules, while the human sequence (VHFFKNIVTPRTP) allows for comparative studies of human autoimmune responses.

2.PRODUCT INDICATIONS

EAE Model Development: Induction of experimental autoimmune encephalomyelitis in susceptible animal models

Multiple Sclerosis Research: Study of autoimmune demyelination mechanisms and neuroinflammation

T Cell Epitope Mapping: Identification and characterization of autoreactive T cell epitopes

Species-Specific Immune Response: Comparative analysis of human vs. guinea pig epitope recognition

Autoimmune T Cell Activation: Investigation of T cell activation, proliferation, and cytokine production

Immunotherapy Development: Screening and evaluation of therapeutic interventions for autoimmune diseases

3.CLINICAL EFFICACY OF PRODUCT

Sequence Authenticity: Verified VHFFKNIVTPRTP (human) and VHFFKNIVTPHPQ (guinea pig) sequences

Biological Activity: Validated in EAE induction models, T cell proliferation assays, and MHC binding studies

Species-Specific Potency: Confirmed differential encephalitogenic activity between human and guinea pig sequences

Research Reproducibility: Consistent performance in autoimmune disease models and immunological assays

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.