MBP (87-99), human; Myelin Basic Protein (87-99), guinea pig, human CAS NO.118506-26-6
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | MBP (87-99), human; Myelin Basic Protein (87-99), guinea pig, human |
| CAS NO. | 118506-26-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C74H114N20O17 |
| Molecular Weight | 1555.86g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, PBS (pH 7-8), or an aqueous solution containing a small amount of DMSO. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Autoimmune epitopes of myelin basic proteins; can induce experimental autoimmune encephalomyelitis (EAE), used for multiple sclerosis models, T-cell epitope and autoimmune research. |
| Storage Conditions | Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The MBP 87-99 peptide functions as a major encephalitogenic epitope that induces autoimmune responses through MHC class II presentation. Antigen-presenting cells (APCs) process and present the peptide via MHC class II molecules to CD4⁺ T helper cells. The specific interaction between the peptide-MHC complex and T cell receptors (TCRs) activates autoreactive T cells, leading to their proliferation and differentiation into Th1 or Th17 effector cells. These activated T cells migrate across the blood-brain barrier, recognize myelin basic protein in the central nervous system, and initiate an inflammatory cascade involving cytokine release, macrophage activation, and demyelination. The guinea pig sequence (VHFFKNIVTPHPQ) is particularly potent in inducing EAE in susceptible animal strains due to its high affinity for certain MHC class II molecules, while the human sequence (VHFFKNIVTPRTP) allows for comparative studies of human autoimmune responses.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
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