[Cys18]-Atrial Natriuretic Factor (4-18) amide (rat) CAS NO.111863-73-1

[Cys18]-Atrial Natriuretic Factor (4-18) amide (rat) CAS NO.111863-73-1

[Cys18]-Atrial Natriuretic Factor (4-18) amide (rat) (CAS NO. 111863-73-1) is a high‑purity synthetic peptide analogue of rat atrial natriuretic factor (ANF). This modified peptide is designed for cardiovascular, renal, and endocrine research, particularly in studies of fluid‑electrolyte balance and blood pressure regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Cys18]-Atrial Natriuretic Factor (4-18) amide (rat)
CAS NO.	111863-73-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C64H107N25O19S2
Amino Acid Sequence	H‑Ser‑Leu‑Arg‑Arg‑Ser‑Ser‑Cys‑Phe‑Gly‑Gly‑Arg‑Ile‑Asp‑Arg‑Ile‑Gly‑Ala‑Cys‑NH₂ (rat ANF residues 4‑18 with Cys at position 18 and C‑terminal amidation)
Molecular Weight	1594.9g/mol
Purity (RP-HPLC)	≥95.0% (typical for custom research peptides)
Solubility	Soluble in water, 0.1 M acetic acid, or phosphate-buffered saline (PBS)
Endotoxin	< 1.0 EU/mg
Biological Activity	Modified atrial natriuretic peptide fragment; binds to natriuretic peptide receptors (NPR‑A/NPR‑B) and stimulates cGMP production, used in cardiovascular and renal physiology research.
Storage Conditions	Store at –20°C (lyophilized) or –80°C (solution). Protect from light and repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1mg

1.MECHANISM OF ACTION

This peptide binds to natriuretic peptide receptors (NPR‑A/NPR‑B) and stimulates the production of intracellular cyclic guanosine monophosphate (cGMP). This signaling cascade promotes vasodilation, natriuresis, and diuresis, thereby contributing to the regulation of blood pressure and fluid homeostasis.

2.PRODUCT INDICATIONS

[Cys18]-ANF (4-18) amide is used in preclinical research to investigate the physiological roles of natriuretic peptides, including their effects on cardiovascular function, renal sodium excretion, and hormone‑mediated fluid balance. It is also employed in receptor‑binding assays and the study of peptide structure‑activity relationships.

3.CLINICAL EFFICACY OF PRODUCT

As a research tool, this peptide is not intended for direct clinical application. However, it enables the characterization of ANF receptor interactions and downstream signaling pathways, providing valuable insights that support the development of novel therapeutics for hypertension, heart failure, and renal disorders.

4.DELIVERY & SHIPPING

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