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[Cys18]-Atrial Natriuretic Factor (4-18) amide (rat) CAS NO.111863-73-1
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Cys18]-Atrial Natriuretic Factor (4-18) amide (rat) |
| CAS NO. | 111863-73-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C64H107N25O19S2 |
| Amino Acid Sequence | H‑Ser‑Leu‑Arg‑Arg‑Ser‑Ser‑Cys‑Phe‑Gly‑Gly‑Arg‑Ile‑Asp‑Arg‑Ile‑Gly‑Ala‑Cys‑NH₂ (rat ANF residues 4‑18 with Cys at position 18 and C‑terminal amidation) |
| Molecular Weight | 1594.9g/mol |
| Purity (RP-HPLC) | ≥95.0% (typical for custom research peptides) |
| Solubility | Soluble in water, 0.1 M acetic acid, or phosphate-buffered saline (PBS) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Modified atrial natriuretic peptide fragment; binds to natriuretic peptide receptors (NPR‑A/NPR‑B) and stimulates cGMP production, used in cardiovascular and renal physiology research. |
| Storage Conditions | Store at –20°C (lyophilized) or –80°C (solution). Protect from light and repeated freeze‑thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
This peptide binds to natriuretic peptide receptors (NPR‑A/NPR‑B) and stimulates the production of intracellular cyclic guanosine monophosphate (cGMP). This signaling cascade promotes vasodilation, natriuresis, and diuresis, thereby contributing to the regulation of blood pressure and fluid homeostasis.
2.PRODUCT INDICATIONS
[Cys18]-ANF (4-18) amide is used in preclinical research to investigate the physiological roles of natriuretic peptides, including their effects on cardiovascular function, renal sodium excretion, and hormone‑mediated fluid balance. It is also employed in receptor‑binding assays and the study of peptide structure‑activity relationships.
3.CLINICAL EFFICACY OF PRODUCT
As a research tool, this peptide is not intended for direct clinical application. However, it enables the characterization of ANF receptor interactions and downstream signaling pathways, providing valuable insights that support the development of novel therapeutics for hypertension, heart failure, and renal disorders.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
