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Atrial Natriuretic Factor (3-28) (human) CAVS NO.102686-43-1

Atrial Natriuretic Factor (3-28) (human) | CAS 102686-43-1 is a high-purity (≥98% RP-HPLC) research-grade peptide with a molecular formula of C₁₁₇H₁₈₇N₄₃O₃₆S₃ and molecular weight of 2880.3 g/mol. As a potent NPR-A agonist, it is ideal for preclinical research on hypertension, heart failure, and renal function regulation, featuring low endotoxin (<0.1 EU/μg) and reliable biological activity. We offer customizable bulk orders (10 mg–100 g) and global shipping, serving as a trusted supplier for academic and pharmaceutical R&D teams seeking high-quality natriuretic peptide reagents.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Atrial Natriuretic Factor (3-28) (human)
CAS NO.	102686-43-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₁₇H₁₈₇N₄₃O₃₆S₃
Molecular Weight	2880.3 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL), PBS (pH 7.4), DMSO; slightly soluble in ethanol
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of natriuretic peptide receptor A (NPR-A); induces vasorelaxation, natriuresis, diuresis, and inhibits renin-angiotensin-aldosterone system (RAAS) and cardiac hypertrophy
Storage Conditions	-20°C (short-term, 1-2 years); -80°C (long-term, 3-5 years), avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Atrial Natriuretic Factor (3-28) (human) is a biologically active fragment of native atrial natriuretic factor (ANF), functioning as a potent and selective agonist of natriuretic peptide receptor A (NPR-A), also known as guanylate cyclase-A. Upon binding to NPR-A expressed on vascular smooth muscle cells, cardiomyocytes, renal tubular cells, and adrenal glands, this peptide activates the receptor’s guanylate cyclase activity, triggering the intracellular synthesis of cyclic guanosine monophosphate (cGMP)—a key second messenger. The elevated cGMP levels initiate downstream signaling cascades that exert multiple physiological effects, including vasorelaxation (dilation of blood vessels to reduce peripheral resistance), natriuresis (enhanced sodium excretion via the kidneys), and diuresis (increased water excretion). Additionally, it inhibits the renin-angiotensin-aldosterone system (RAAS), a critical pathway in blood pressure regulation, and suppresses cardiac hypertrophy and fibrosis by blocking pro-hypertrophic and pro-fibrotic signaling molecules, thereby protecting cardiovascular homeostasis.

2.PRODUCT INDICATIONS

This high-purity research-grade Atrial Natriuretic Factor (3-28) (human) is specifically developed for preclinical research and pharmaceutical drug development, targeting cardiovascular, renal, and metabolic disease areas. Its key applications include investigating the mechanisms of hypertension, heart failure, and cardiac remodeling; studying renal function regulation, sodium-water homeostasis, and chronic kidney disease (CKD) progression; evaluating vascular endothelial function, atherosclerosis, and vascular smooth muscle cell proliferation; developing novel therapeutics for hypertension-related end-organ damage and metabolic syndrome; and conducting basic research on natriuretic peptide signaling pathways and NPR-A ligand-receptor interaction dynamics. It is widely used in academic laboratories and pharmaceutical R&D projects as a reliable tool reagent.

3.CLINICAL EFFICACY OF PRODUCT

In hypertensive rodent models, it effectively reduces systemic blood pressure by inducing vasorelaxation and inhibiting RAAS activation, with a rapid onset of action and good safety profile. In heart failure models, it attenuates cardiac hypertrophy and interstitial fibrosis, improves cardiac contractility and diastolic function, and reduces ventricular remodeling. For renal disease models, it enhances glomerular filtration rate (GFR), promotes sodium and water excretion, and alleviates renal interstitial fibrosis, showing potential in delaying CKD progression.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.