Atrial Natriuretic Factor (3-28) (human) CAVS NO.102686-43-1
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Atrial Natriuretic Factor (3-28) (human) |
| CAS NO. | 102686-43-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₁₇H₁₈₇N₄₃O₃₆S₃ |
| Molecular Weight | 2880.3 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥1 mg/mL), PBS (pH 7.4), DMSO; slightly soluble in ethanol |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Potent agonist of natriuretic peptide receptor A (NPR-A); induces vasorelaxation, natriuresis, diuresis, and inhibits renin-angiotensin-aldosterone system (RAAS) and cardiac hypertrophy |
| Storage Conditions | -20°C (short-term, 1-2 years); -80°C (long-term, 3-5 years), avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Atrial Natriuretic Factor (3-28) (human) is a biologically active fragment of native atrial natriuretic factor (ANF), functioning as a potent and selective agonist of natriuretic peptide receptor A (NPR-A), also known as guanylate cyclase-A. Upon binding to NPR-A expressed on vascular smooth muscle cells, cardiomyocytes, renal tubular cells, and adrenal glands, this peptide activates the receptor’s guanylate cyclase activity, triggering the intracellular synthesis of cyclic guanosine monophosphate (cGMP)—a key second messenger. The elevated cGMP levels initiate downstream signaling cascades that exert multiple physiological effects, including vasorelaxation (dilation of blood vessels to reduce peripheral resistance), natriuresis (enhanced sodium excretion via the kidneys), and diuresis (increased water excretion). Additionally, it inhibits the renin-angiotensin-aldosterone system (RAAS), a critical pathway in blood pressure regulation, and suppresses cardiac hypertrophy and fibrosis by blocking pro-hypertrophic and pro-fibrotic signaling molecules, thereby protecting cardiovascular homeostasis.
2.PRODUCT INDICATIONS
This high-purity research-grade Atrial Natriuretic Factor (3-28) (human) is specifically developed for preclinical research and pharmaceutical drug development, targeting cardiovascular, renal, and metabolic disease areas. Its key applications include investigating the mechanisms of hypertension, heart failure, and cardiac remodeling; studying renal function regulation, sodium-water homeostasis, and chronic kidney disease (CKD) progression; evaluating vascular endothelial function, atherosclerosis, and vascular smooth muscle cell proliferation; developing novel therapeutics for hypertension-related end-organ damage and metabolic syndrome; and conducting basic research on natriuretic peptide signaling pathways and NPR-A ligand-receptor interaction dynamics. It is widely used in academic laboratories and pharmaceutical R&D projects as a reliable tool reagent.
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
