Neurokinin A; Substance K; Neuromedin L; NKA CAS NO.86933-74-6

Neurokinin A (NKA), also known as Substance K or Neuromedin L, is an endogenous tachykinin decapeptide that serves as a key signaling molecule in neuroendocrine and inflammatory pathways. This research-grade synthetic peptide is supplied as a lyophilized powder with ≥95% HPLC purity, low endotoxin levels, and confirmed biological activity at neurokinin receptors. It is widely used as a standard agonist in receptor binding studies, functional assays, and pharmacological characterization of tachykinin signaling in respiratory, gastrointestinal, and cardiovascular systems.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neurokinin A; Substance K; Neuromedin L; NKA
CAS NO.	86933-74-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C50H80N14O14S
Molecular Weight	1133.34g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1 % v/v). For best results, first dissolve in a small volume of 0.1 % acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution, then dilute with the desired assay buffer.
Endotoxin	< 1.0 EU/mg
Biological Activity	Neurokinin A is an endogenous tachykinin peptide that acts as a high‑affinity agonist primarily at neurokinin‑2 receptors (NK₂R). It mediates smooth‑muscle contraction (especially in bronchial and gastrointestinal tracts), vasodilation, and neurogenic inflammation. Biological activity is typically confirmed in NK₂R‑expressing cell‑based assays (e.g., calcium mobilization, IP₃ accumulation) or isolated tissue contraction bioassays.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neurokinin A acts primarily as a high-affinity agonist at neurokinin-2 receptors (NK₂R), binding to these G protein-coupled receptors to activate phospholipase C via Gq/11 coupling. This leads to increased production of inositol trisphosphate (IP₃) and diacylglycerol (DAG), resulting in calcium mobilization from intracellular stores. The subsequent signaling cascade mediates smooth muscle contraction in bronchial and gastrointestinal tissues, promotes neurogenic inflammation, and induces vasodilation. NKA also exhibits lower affinity for NK₁ and NK₃ receptors, contributing to its broad physiological effects in both central and peripheral nervous systems.

2.PRODUCT INDICATIONS

This Neurokinin A peptide is indicated exclusively for research use in preclinical studies of tachykinin receptor biology and neuroinflammatory pathways. It is employed as a standard agonist in receptor binding assays, calcium mobilization studies, and smooth muscle contraction bioassays to characterize NK₂R function in respiratory, gastrointestinal, and cardiovascular research. The product serves as a reference compound for screening NK₂R antagonists, studying neurogenic inflammation mechanisms, and investigating tachykinin signaling in disease models. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Neurokinin A has no established clinical efficacy for therapeutic use in human patients. The product has not undergone clinical development, regulatory approval, or safety evaluation for any medical indication. While endogenous NKA plays important roles in asthma, irritable bowel syndrome, and inflammatory pain pathways, this synthetic peptide is solely an investigational tool for basic and translational research. Its utility is confined to laboratory applications, with no proven clinical benefits or safety profile in humans.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.