[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B CAS NO.109212-72-8

[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B CAS NO.109212-72-8

[D‑Pro², D‑Trp⁶⁸, Nle¹⁰]‑Neurokinin B (CAS NO. 109212‑72‑8) is a high‑purity modified neurokinin peptide designed for advanced neuropharmacology and receptor research.This analogue exhibits enhanced receptor selectivity and metabolic stability, making it a valuable tool for studying tachykinin signaling pathways.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[D‑Pro², D‑Trp⁶⁸, Nle¹⁰]‑Neurokinin B
CAS NO.	109212-72-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C67H87N15O14
Amino Acid Sequence	H‑Asp‑D‑Pro‑Lys‑Pro‑Asp‑D‑Trp‑Phe‑D‑Trp‑Leu‑Nle‑NH₂
Molecular Weight	1326.53g/mol
Purity (RP-HPLC)	≥97.0% (customizable to ≥98.0%)
Solubility	Soluble in water, 0.1 M acetic acid, or PBS (pH 7.0‑7.4)
Endotoxin	< 1.0 EU/mg
Biological Activity	Modified neurokinin B analogue with enhanced receptor selectivity and metabolic stability; acts as a potent NK₃ receptor antagonist or agonist (depending on configuration), used in neuropharmacology and tachykinin signaling research.
Storage Conditions	Store at –20 °C, protected from light and moisture. For long‑term storage, recommend –80 °C.
Stock Location	Stock in USA
MOQ	1mg

1.MECHANISM OF ACTION

This modified peptide functions as a selective ligand for neurokinin receptors (particularly NK₃), modulating intracellular signaling cascades such as calcium mobilization and phospholipase C activation. Its D‑amino acid substitutions and norleucine modification enhance resistance to enzymatic degradation, leading to prolonged receptor interaction and more stable pharmacological effects in experimental models.

2.PRODUCT INDICATIONS

[D‑Pro², D‑Trp⁶⁸, Nle¹⁰]‑Neurokinin B is used in research on neuroendocrine regulation, pain transmission, smooth muscle contraction, and psychiatric disorders. It is also applied in drug‑discovery assays targeting NK₃ receptors and in studies of reproductive physiology, stress responses, and inflammatory conditions.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical studies demonstrate that this analogue effectively modulates neurokinin‑mediated processes, including hormone secretion and neuronal excitability. While not a therapeutic itself, it provides a robust pharmacological probe for validating NK₃ receptor pathways and supports the development of novel treatments for conditions such as schizophrenia, chronic pain, and hormone‑related disorders.

4.DELIVERY & SHIPPING

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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight

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