![[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B CAS NO.109212-72-8](https://images.cnmqh.com/images/a10134/20260130114243_258_1-20260130034308.webp "[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B CAS NO.109212-72-8")
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[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B CAS NO.109212-72-8
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [D‑Pro², D‑Trp⁶⁸, Nle¹⁰]‑Neurokinin B |
| CAS NO. | 109212-72-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C67H87N15O14 |
| Amino Acid Sequence | H‑Asp‑D‑Pro‑Lys‑Pro‑Asp‑D‑Trp‑Phe‑D‑Trp‑Leu‑Nle‑NH₂ |
| Molecular Weight | 1326.53g/mol |
| Purity (RP-HPLC) | ≥97.0% (customizable to ≥98.0%) |
| Solubility | Soluble in water, 0.1 M acetic acid, or PBS (pH 7.0‑7.4) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Modified neurokinin B analogue with enhanced receptor selectivity and metabolic stability; acts as a potent NK₃ receptor antagonist or agonist (depending on configuration), used in neuropharmacology and tachykinin signaling research. |
| Storage Conditions | Store at –20 °C, protected from light and moisture. For long‑term storage, recommend –80 °C. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
This modified peptide functions as a selective ligand for neurokinin receptors (particularly NK₃), modulating intracellular signaling cascades such as calcium mobilization and phospholipase C activation. Its D‑amino acid substitutions and norleucine modification enhance resistance to enzymatic degradation, leading to prolonged receptor interaction and more stable pharmacological effects in experimental models.
2.PRODUCT INDICATIONS
[D‑Pro², D‑Trp⁶⁸, Nle¹⁰]‑Neurokinin B is used in research on neuroendocrine regulation, pain transmission, smooth muscle contraction, and psychiatric disorders. It is also applied in drug‑discovery assays targeting NK₃ receptors and in studies of reproductive physiology, stress responses, and inflammatory conditions.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical studies demonstrate that this analogue effectively modulates neurokinin‑mediated processes, including hormone secretion and neuronal excitability. While not a therapeutic itself, it provides a robust pharmacological probe for validating NK₃ receptor pathways and supports the development of novel treatments for conditions such as schizophrenia, chronic pain, and hormone‑related disorders.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
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