Neuromedin B, porcine CAS NO.87096-84-2

Neuromedin B, porcine (CAS 87096-84-2) is a high-purity (up to ≥98% RP-HPLC) bombesin-like peptide with molecular formula C₅₂H₇₇N₁₅O₁₂S and molecular weight 1132.3 g/mol. As a selective NMB-R ligand (IC₅₀=2 nM), it mediates smooth muscle contraction and regulates endocrine function, ideal for neuroscience, gastroenterology, and oncology research. Featuring -20℃ short-term storage compatibility, low endotoxin, customizable bulk orders (10 mg–100 g), and batch-specific quality reports, we are a trusted supplier of porcine NMB with global shipping and rigorous quality control.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuromedin B, porcine
CAS NO.	87096-84-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C₅₂H₇₇N₁₅O₁₂S
Molecular Weight	1132.3g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in sterile water,slightly soluble in ethanol; ≥20.6 mg/mL in DMSO; insoluble in non-polar solvents
Endotoxin	< 1.0 EU/mg
Biological Activity	Endogenous ligand for neuromedin B receptor (NMB-R) with IC₅₀=2 nM; regulates endocrine/exocrine secretion, smooth muscle contraction , blood pressure, feeding behavior, body temperature and cell growth; relative potency for uterine smooth muscle contraction is 4.9% of bombesin (BN) on molar basis
Storage Conditions	-20℃ for short-term storage
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neuromedin B, porcine is an endogenous bombesin-like peptide and a high-affinity ligand for the neuromedin B receptor (NMB-R), a G-protein coupled receptor (GPCR) widely expressed in the central nervous system (CNS), gastrointestinal tract, respiratory system, and certain tumor cells. With an IC₅₀ value of 2 nM for NMB-R binding, it activates Gq/11 and Gi/o-dependent intracellular signaling pathways upon receptor ligation. This activation triggers hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate inositol trisphosphate (IP3) and diacylglycerol (DAG), elevating intracellular calcium levels to mediate smooth muscle contraction

2.PRODUCT INDICATIONS

Investigation of NMB-R signaling pathways in smooth muscle contraction, endocrine/exocrine regulation, and neuronal function

Screening and validation of NMB-R agonists/antagonists using in vitro assays (e.g., receptor binding assays, calcium mobilization assays)

Study of bombesin-like peptide family biology and their roles in feeding behavior, body temperature homeostasis, and blood pressure regulation

3.CLINICAL EFFICACY OF PRODUCT

In smooth muscle contraction assays (e.g., rat uterus, stomach strip preparations), it serves as a reliable positive control to evaluate the potency of NMB-R-targeted drugs for gastrointestinal and reproductive disorders

In murine models of feeding disorders and metabolic syndrome, it aids in elucidating the role of NMB-NMB-R signaling in appetite regulation, supporting the development of anti-obesity therapeutics

In oncology research, it facilitates the study of NMB-R overexpression in tumor cells, providing insights for developing targeted anti-tumor therapies and diagnostic markers

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.