Biotin-Neuromedin S (rat)

Biotin-Neuromedin S (rat) is a synthetic, biotin-conjugated peptide corresponding to the rat isoform of Neuromedin S (NMS). This high-purity research reagent combines the full biological activity of endogenous rat NMS with a biotin tag, enabling its specific immobilization, capture, and highly sensitive detection in streptavidin-based assay systems. It is a crucial tool for elucidating the neuromedin S signaling pathway in rodent models of circadian biology, metabolism, and neuroendocrinology.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin-Neuromedin S (rat)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C67H87N15O14
Molecular Weight	1326.53/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid & DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent agonist for rat neuromedin U receptors (NMU1/NMU2) with retained native bioactivity, EC₅₀ ≈ 0.3–2.0 nM in calcium mobilization functional assays.
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This conjugate acts as a potent and selective endogenous agonist for the neuromedin U receptor 2 (NMUR2), which is highly expressed in the suprachiasmatic nucleus (SCN) of the brain. The biotin moiety, attached via a spacer, does not impede the peptide's receptor-binding domain. Upon engaging NMUR2, it activates Gq protein-coupled signaling, stimulating phospholipase C (PLC). This leads to the production of inositol trisphosphate (IP₃) and diacylglycerol (DAG), culminating in intracellular calcium mobilization.

2.PRODUCT INDICATIONS

This product is indicated for advanced molecular and in vitro research using rodent systems. Key applications include: performing surface plasmon resonance (SPR) or biolayer interferometry (BLI) to quantify binding kinetics and affinity for the rat NMUR2 receptor, conducting pull-down or co-immunoprecipitation assays to isolate receptor complexes, developing sensitive capture-based immunoassays (e.g., ELISA) for NMS detection, and receptor localization studies in tissue sections or cultured cells using streptavidin-based detection methods.

3.CLINICAL EFFICACY OF PRODUCT

Biotin-Neuromedin S (rat) is a specialized research tool and not a direct therapeutic. Its efficacy lies in its role as an enabling reagent for high-precision biomedical research. By allowing detailed molecular interaction studies in rodent models, it facilitates a deeper understanding of the NMS/NMUR2 pathway's role in regulating circadian rhythms and energy balance.

4.DELIVERY & SHIPPING

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