Name: Biotin-Neuromedin S for Enhanced Rat Health and Growth
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Biotin-Neuromedin S (rat)

Biotin-Neuromedin S (rat) is a synthetic, biotin-conjugated peptide corresponding to the rat isoform of Neuromedin S (NMS). This high-purity research reagent combines the full biological activity of endogenous rat NMS with a biotin tag, enabling its specific immobilization, capture, and highly sensitive detection in streptavidin-based assay systems. It is a crucial tool for elucidating the neuromedin S signaling pathway in rodent models of circadian biology, metabolism, and neuroendocrinology.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin-Neuromedin S (rat)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C67H87N15O14
Molecular Weight	1326.53/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid & DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent agonist for rat neuromedin U receptors (NMU1/NMU2) with retained native bioactivity, EC₅₀ ≈ 0.3–2.0 nM in calcium mobilization functional assays.
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This conjugate acts as a potent and selective endogenous agonist for the neuromedin U receptor 2 (NMUR2), which is highly expressed in the suprachiasmatic nucleus (SCN) of the brain. The biotin moiety, attached via a spacer, does not impede the peptide's receptor-binding domain. Upon engaging NMUR2, it activates Gq protein-coupled signaling, stimulating phospholipase C (PLC). This leads to the production of inositol trisphosphate (IP₃) and diacylglycerol (DAG), culminating in intracellular calcium mobilization.

2.PRODUCT INDICATIONS

This product is indicated for advanced molecular and in vitro research using rodent systems. Key applications include: performing surface plasmon resonance (SPR) or biolayer interferometry (BLI) to quantify binding kinetics and affinity for the rat NMUR2 receptor, conducting pull-down or co-immunoprecipitation assays to isolate receptor complexes, developing sensitive capture-based immunoassays (e.g., ELISA) for NMS detection, and receptor localization studies in tissue sections or cultured cells using streptavidin-based detection methods.

3.CLINICAL EFFICACY OF PRODUCT

Biotin-Neuromedin S (rat) is a specialized research tool and not a direct therapeutic. Its efficacy lies in its role as an enabling reagent for high-precision biomedical research. By allowing detailed molecular interaction studies in rodent models, it facilitates a deeper understanding of the NMS/NMUR2 pathway's role in regulating circadian rhythms and energy balance.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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