Neuropeptide Y, human, rat CAS NO.90880-35-6

Neuropeptide Y, human, rat is a highly conserved 36-amino acid neuropeptide supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels, featuring an amidated C-terminus essential for biological activity. This research-grade peptide is identical in sequence between human and rat, making it a versatile tool for cross-species studies of NPY signaling pathways. It is designed for receptor binding assays, functional studies in appetite regulation, energy homeostasis, and cardiovascular research, providing a standardized agonist for Y receptor family investigations in both central and peripheral nervous system models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide Y, human, rat
CAS NO.	90880-35-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C189H285N55O57S
Molecular Weight	4271.7g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid (e.g., 0.1% v/v), or phosphate-buffered saline (PBS). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution, then dilute with the desired assay buffer.
Endotoxin	< 1.0 EU/mg
Biological Activity	Neuropeptide Y (NPY) is a potent 36-amino acid neuropeptide that acts as a high-affinity agonist at Y1, Y2, Y4, Y5, and Y6 receptors (Y1R, Y2R, etc.). It is one of the most abundant and conserved neuropeptides in the central and peripheral nervous systems, involved in regulating energy homeostasis, appetite stimulation, anxiety, stress response, vasoconstriction, and memory processing. Biological activity is typically confirmed by receptor-binding assays (e.g., competitive binding to Y1R) or functional assays (e.g., cAMP inhibition in Y1R-expressing cells).
Storage Conditions	Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long-term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze-thaw cycles. For extended stability, store at –80°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neuropeptide Y exerts its effects by binding with high affinity to G protein-coupled Y receptors (Y1, Y2, Y4, Y5, Y6), primarily coupling to Gi/o proteins to inhibit adenylate cyclase and reduce intracellular cAMP levels. This activation leads to modulation of calcium and potassium channels, resulting in diverse physiological responses including appetite stimulation, vasoconstriction, and anxiolytic effects. The peptide's conserved structure allows for potent activation across multiple receptor subtypes, with its amidated C-terminus being critical for receptor recognition and signaling efficacy in both human and rodent systems.

2.PRODUCT INDICATIONS

This NPY peptide is indicated exclusively for research applications investigating neuropeptide Y signaling pathways in human and rodent models. It is employed in receptor binding studies, functional assays measuring cAMP inhibition, appetite regulation research, cardiovascular physiology experiments, and anxiety/stress response investigations. The product serves as a reference agonist for validating Y receptor expression, screening receptor antagonists, and studying NPY's role in metabolic disorders and neurological conditions. It is not intended for diagnostic, therapeutic, or clinical use in humans or animals.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Neuropeptide Y, human, rat has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of NPY biology and may inform therapeutic strategies targeting Y receptors for obesity, anxiety, or cardiovascular disorders, its utility remains confined to laboratory research. Any clinical translation would require development of entirely distinct therapeutic agents with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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