Urocortin II, human CAS NO.398001-88-2

Urocortin II, human is a 38-amino acid C-terminal amidated neuropeptide that functions as a selective agonist for corticotropin-releasing hormone receptor 2 (CRHR2), supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide is derived from the human sequence and is designed for studies of stress response, anxiety, appetite regulation, and cardiovascular function in human-relevant in vitrosystems. It serves as a critical tool for investigating CRHR2-mediated signaling pathways and the physiological roles of the urocortin system in energy homeostasis and stress adaptation, providing researchers with a reliable reagent for dissecting species-specific effects.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Urocortin II, human
CAS NO.	398001-88-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C194H338N63O54S1
Molecular Weight	4449.31g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Human urocortin II is a selective agonist for the corticotropin‑releasing hormone receptor 2 (CRHR2). It mediates stress‑related responses, including anxiety‑like behaviors, appetite suppression, and cardiovascular effects. Bioactivity can be validated in CRHR2‑expressing cell‑based assays (e.g., cAMP accumulation).
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Urocortin II, human selectively binds to CRHR2 with high affinity, activating Gs-coupled signaling pathways that stimulate adenylate cyclase and elevate intracellular cAMP levels. This activation modulates downstream effectors involved in stress response, including regulation of hypothalamic-pituitary-adrenal axis activity, neurotransmitter release, and cardiovascular function through vasodilation and positive inotropy. The peptide exhibits minimal cross-reactivity with CRHR1, making it an ideal tool for studying CRHR2-specific physiological responses such as anxiety-like behaviors, appetite suppression, and stress-induced cardiovascular changes in human cell-based models and cross-species comparisons.

2.PRODUCT INDICATIONS

This peptide is indicated for research applications focused on stress physiology, anxiety disorders, appetite regulation, and cardiovascular function in human-relevant in vitrosystems. It is utilized in in vitroassays with CRHR2-expressing cells to study cAMP accumulation, receptor binding kinetics, and signal transduction pathways. The product also serves as a reference standard for autoradiography, immunohistochemistry, and functional studies to localize CRHR2 expression and activity in human tissues and cell lines, contributing to the understanding of stress-related and metabolic disorders.

3.CLINICAL EFFICACY OF PRODUCT

Urocortin II, human has no clinical efficacy or safety profile, as it is strictly a research reagent for preclinical investigations. The peptide has not undergone clinical trials, regulatory evaluation, or safety assessment for diagnostic or therapeutic use in humans. While preclinical studies demonstrate its potent effects on stress response and cardiovascular function in human cell-based models, these findings remain exploratory and have not been translated into validated clinical interventions. Any potential therapeutic applications would require the development of distinct agents with comprehensive pharmacokinetic and safety evaluations.

4.DELIVERY & SHIPPING

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