Urocortin II, human CAS NO.398001-88-2
Urocortin II, human CAS NO.398001-88-2
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Urocortin II, human |
| CAS NO. | 398001-88-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C194H338N63O54S1 |
| Molecular Weight | 4449.31g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Human urocortin II is a selective agonist for the corticotropin‑releasing hormone receptor 2 (CRHR2). It mediates stress‑related responses, including anxiety‑like behaviors, appetite suppression, and cardiovascular effects. Bioactivity can be validated in CRHR2‑expressing cell‑based assays (e.g., cAMP accumulation). |
| Storage Conditions | Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Urocortin II, human selectively binds to CRHR2 with high affinity, activating Gs-coupled signaling pathways that stimulate adenylate cyclase and elevate intracellular cAMP levels. This activation modulates downstream effectors involved in stress response, including regulation of hypothalamic-pituitary-adrenal axis activity, neurotransmitter release, and cardiovascular function through vasodilation and positive inotropy. The peptide exhibits minimal cross-reactivity with CRHR1, making it an ideal tool for studying CRHR2-specific physiological responses such as anxiety-like behaviors, appetite suppression, and stress-induced cardiovascular changes in human cell-based models and cross-species comparisons.
2.PRODUCT INDICATIONS
This peptide is indicated for research applications focused on stress physiology, anxiety disorders, appetite regulation, and cardiovascular function in human-relevant in vitrosystems. It is utilized in in vitroassays with CRHR2-expressing cells to study cAMP accumulation, receptor binding kinetics, and signal transduction pathways. The product also serves as a reference standard for autoradiography, immunohistochemistry, and functional studies to localize CRHR2 expression and activity in human tissues and cell lines, contributing to the understanding of stress-related and metabolic disorders.
3.CLINICAL EFFICACY OF PRODUCT
Urocortin II, human has no clinical efficacy or safety profile, as it is strictly a research reagent for preclinical investigations. The peptide has not undergone clinical trials, regulatory evaluation, or safety assessment for diagnostic or therapeutic use in humans. While preclinical studies demonstrate its potent effects on stress response and cardiovascular function in human cell-based models, these findings remain exploratory and have not been translated into validated clinical interventions. Any potential therapeutic applications would require the development of distinct agents with comprehensive pharmacokinetic and safety evaluations.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
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