Neurotensin (8-13) CAS NO.60482-95-3

Neurotensin (8-13) (CAS NO. 60482-95-3) is a synthetic hexapeptide representing the C-terminal active core fragment of the full-length neurotensin (NT) neuropeptide. This high-purity, research-grade fragment (Arg-Arg-Pro-Tyr-Ile-Leu) retains the full biological activity of native NT but offers enhanced metabolic stability and potency. It serves as a fundamental and potent agonist for neurotensin receptor studies.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neurotensin (8-13)
CAS NO.	60482-95-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C38H64N12O8
Molecular Weight	817.01/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (up to 10 mg/mL), dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent agonist of the neurotensin receptor (NTS1 and NTS2).
Storage Conditions	Store desiccated at -20°C to -80°C; avoid repeated freeze-thaw cycles. Stable for 2–3 years under proper storage.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide acts as a potent agonist for neurotensin receptors, primarily NTS1 and NTS2. The C-terminal hexapeptide sequence constitutes the minimal fragment required for high-affinity receptor binding and activation. Upon binding, it triggers Gq protein-mediated signaling, leading to phospholipase C (PLC) activation. This results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG), causing intracellular calcium mobilization and protein kinase C (PKC) activation.

2.PRODUCT INDICATIONS

This product is indicated for a wide range of in vitro and in vivo research in neuroscience, pharmacology, and oncology. Key applications include: studying neurotensin receptor pharmacology and downstream signaling pathways, investigating its roles in pain modulation, body temperature regulation, and antipsychotic-like effects, exploring its mitogenic and proliferative effects in cancer models (e.g., pancreatic, colon), and serving as a standard high-potency agonist in receptor binding assays and functional studies (e.g., calcium mobilization).

3.CLINICAL EFFICACY OF PRODUCT

Neurotensin (8-13) is a potent research tool and not a clinical drug. Its "efficacy" is defined by its critical role in validating the neurotensin system as a therapeutic target. Preclinical research using this fragment has been pivotal in demonstrating NT's involvement in pain pathways, schizophrenia-related behaviors, and cancer cell proliferation. .

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.