Name: Neurotensin (8-13) CAS 60482-95-3 - Premium Research Peptide
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Neurotensin (8-13) CAS NO.60482-95-3

Neurotensin (8-13) (CAS NO. 60482-95-3) is a synthetic hexapeptide representing the C-terminal active core fragment of the full-length neurotensin (NT) neuropeptide. This high-purity, research-grade fragment (Arg-Arg-Pro-Tyr-Ile-Leu) retains the full biological activity of native NT but offers enhanced metabolic stability and potency. It serves as a fundamental and potent agonist for neurotensin receptor studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neurotensin (8-13)
CAS NO.	60482-95-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C38H64N12O8
Molecular Weight	817.01/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (up to 10 mg/mL), dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent agonist of the neurotensin receptor (NTS1 and NTS2).
Storage Conditions	Store desiccated at -20°C to -80°C; avoid repeated freeze-thaw cycles. Stable for 2–3 years under proper storage.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide acts as a potent agonist for neurotensin receptors, primarily NTS1 and NTS2. The C-terminal hexapeptide sequence constitutes the minimal fragment required for high-affinity receptor binding and activation. Upon binding, it triggers Gq protein-mediated signaling, leading to phospholipase C (PLC) activation. This results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG), causing intracellular calcium mobilization and protein kinase C (PKC) activation.

2.PRODUCT INDICATIONS

This product is indicated for a wide range of in vitro and in vivo research in neuroscience, pharmacology, and oncology. Key applications include: studying neurotensin receptor pharmacology and downstream signaling pathways, investigating its roles in pain modulation, body temperature regulation, and antipsychotic-like effects, exploring its mitogenic and proliferative effects in cancer models (e.g., pancreatic, colon), and serving as a standard high-potency agonist in receptor binding assays and functional studies (e.g., calcium mobilization).

3.CLINICAL EFFICACY OF PRODUCT

Neurotensin (8-13) is a potent research tool and not a clinical drug. Its "efficacy" is defined by its critical role in validating the neurotensin system as a therapeutic target. Preclinical research using this fragment has been pivotal in demonstrating NT's involvement in pain pathways, schizophrenia-related behaviors, and cancer cell proliferation. .

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight

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