Neurotensin (Frog)

Neurotensin (Frog) is a synthetic peptide representing the amphibian (frog) isoform of the neurotensin (NT) neuropeptide family. This research-grade peptide exhibits structural similarity to mammalian neurotensin but with specific amino acid sequence variations. It serves as a valuable tool for comparative neuroendocrinology studies, allowing researchers to investigate the evolution, receptor specificity, and conserved biological functions of neurotensin-like peptides across different species.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neurotensin (Frog)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C70H115N23O17
Molecular Weight	1550.84/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water (up to 5 mg/mL), dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent agonist of neurotensin receptors (NTS1 and NTS2). Modulates central nervous system function, pain perception, and dopamine signaling
Storage Conditions	Store desiccated at -20°C to -80°C; avoid repeated freeze-thaw cycles. Stable for 2–3 years under proper storage.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Similar to its mammalian counterpart, Frog Neurotensin is believed to exert its biological effects by activating neurotensin receptors (primarily NTS1 and NTS2), which are G protein-coupled receptors. Upon binding, it likely initiates signaling cascades involving phospholipase C (PLC) activation, leading to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG), resulting in intracellular calcium mobilization and protein kinase C (PKC) activation.

2.PRODUCT INDICATIONS

This product is indicated for specialized research in evolutionary biology, comparative physiology, and receptor pharmacology. Key applications include: studying the phylogenetic conservation and divergence of the neurotensin system across vertebrates, investigating the receptor binding affinity and functional selectivity of non-mammalian NT peptides on mammalian or amphibian receptors, exploring its physiological roles in amphibian models (e.g., smooth muscle contraction, metabolism), and as a unique ligand in structure-activity relationship (SAR) studies to map critical residues for receptor interaction.

3.CLINICAL EFFICACY OF PRODUCT

Neurotensin (Frog) is not a clinical therapeutic but a research probe for basic science. Its "efficacy" lies in its utility for understanding fundamental biological principles. Research using this peptide provides insights into the evolutionary pressures that shape neuropeptide-receptor systems. By comparing frog and mammalian neurotensin, scientists can identify conserved functional domains critical for receptor activation.

4.DELIVERY & SHIPPING

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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight

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