Helospectin II

Helospectin II is a synthetic 38-amino acid peptide belonging to the vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating polypeptide (PACAP) family. Originally isolated from the venom of the Gila monster (Heloderma suspectum), this research-grade peptide is a potent agonist for VIP/PACAP receptors (VPAC1 and VPAC2). It serves as a valuable tool for studying smooth muscle relaxation, neuroendocrine signaling, and cardiovascular regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Helospectin II
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C180H288N46O57
Molecular Weight	4008.58/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥5 mg/mL), dilute acetic acid; slightly soluble in ethanol
Endotoxin	≤1.0 EU/mg
Biological Activity	A vasoactive intestinal peptide (VIP) family neuropeptide; induces vasodilation, lowers blood pressure, activates adenylate cyclase, and modulates smooth muscle relaxation
Storage Conditions	Store at -20°C to -80°C for long-term; short-term storage (≤3 months) at 2°C to 8°C; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Helospectin II exerts its effects by binding to and activating class B G protein-coupled receptors, specifically the VPAC1 and VPAC2 receptors, with which it shares structural homology. Receptor activation primarily stimulates the Gs protein pathway, leading to activation of adenylate cyclase, a significant increase in intracellular cyclic AMP (cAMP) levels, and subsequent activation of protein kinase A (PKA).

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in pharmacology, endocrinology, and physiology. Key applications include: studying VIP/PACAP receptor pharmacology and signaling in comparison to VIP and PACAP; investigating its potent relaxant effects on vascular, respiratory, and gastrointestinal smooth muscle; exploring its potential neuroprotective and secretagogue properties; and serving as a unique natural peptide agonist for receptor binding, cAMP accumulation, and functional relaxation assays.

3.CLINICAL EFFICACY OF PRODUCT

Helospectin II is a natural product research tool, not a clinical therapeutic. Its efficacy is defined by its role as a potent probe for the VIP/PACAP receptor system. Research using this and related peptides from reptile venoms has been instrumental in characterizing the physiology and pharmacology of VPAC receptors. The insights gained contribute to the understanding of this system's role in diseases like asthma, erectile dysfunction, and neurodegenerative disorders, supporting the ongoing search for stable peptide analogs or small-molecule modulators of VPAC receptors for therapeutic use.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.