Helospectin II
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Helospectin II |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C180H288N46O57 |
| Molecular Weight | 4008.58/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥5 mg/mL), dilute acetic acid; slightly soluble in ethanol |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | A vasoactive intestinal peptide (VIP) family neuropeptide; induces vasodilation, lowers blood pressure, activates adenylate cyclase, and modulates smooth muscle relaxation |
| Storage Conditions | Store at -20°C to -80°C for long-term; short-term storage (≤3 months) at 2°C to 8°C; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Helospectin II exerts its effects by binding to and activating class B G protein-coupled receptors, specifically the VPAC1 and VPAC2 receptors, with which it shares structural homology. Receptor activation primarily stimulates the Gs protein pathway, leading to activation of adenylate cyclase, a significant increase in intracellular cyclic AMP (cAMP) levels, and subsequent activation of protein kinase A (PKA).
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
Helospectin II is a natural product research tool, not a clinical therapeutic. Its efficacy is defined by its role as a potent probe for the VIP/PACAP receptor system. Research using this and related peptides from reptile venoms has been instrumental in characterizing the physiology and pharmacology of VPAC receptors. The insights gained contribute to the understanding of this system's role in diseases like asthma, erectile dysfunction, and neurodegenerative disorders, supporting the ongoing search for stable peptide analogs or small-molecule modulators of VPAC receptors for therapeutic use.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
