(Tyr0)Fibrinopeptide A CAS NO.103226-11-5

(Tyr⁰)Fibrinopeptide A (CAS NO. 103226-11-5) is a synthetic, 16-amino acid peptide analog of human Fibrinopeptide A (FpA). This research-grade peptide is modified with an additional N-terminal tyrosine residue (Tyr⁰). It serves as a critical standard and reagent in hemostasis and thrombosis research, specifically for the quantitative measurement of thrombin activity and fibrin formation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	(Tyr⁰)Fibrinopeptide A
CAS NO.	103226-11-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C₇₁H₉₉N₁₉O₂₁S
Molecular Weight	1666.75 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, dilute aqueous acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Modulates platelet aggregation and fibrin formation; mimics the N-terminal extended form of fibrinopeptide A to study thrombin-mediated fibrinogen cleavage.
Storage Conditions	Store at -20°C to -80°C in a dry environment. Lyophilized powder is stable for 24 months at -20°C. Reconstituted solutions should be stored at -20°C and used within 3 months, avoiding repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide functions as a specific substrate for the serine protease thrombin. In the physiological coagulation cascade, thrombin cleaves native Fibrinopeptide A from the Aα chain of fibrinogen, initiating fibrin monomer polymerization. (Tyr⁰)Fibrinopeptide A mimics this natural cleavage site. The added tyrosine residue provides a convenient chromogenic or fluorogenic tag (when coupled to appropriate reporters) or improves detection in immunoassays. The rate of cleavage of this peptide by thrombin is directly proportional to the enzyme's activity, allowing for precise kinetic studies and quantification.

2.PRODUCT INDICATIONS

This product is indicated for specialized research and diagnostic development in the fields of hematology, biochemistry, and clinical pathology. Key applications include: as a high-quality reference standard in the calibration of thrombin activity assays; as a specific chromogenic or fluorogenic substrate in continuous kinetic assays for thrombin activity measurement; in research investigating thrombin inhibitors (e.g., heparin, direct oral anticoagulants) by monitoring their effect on substrate cleavage; and in the development and quality control of diagnostic kits for thrombotic disorders.

3.CLINICAL EFFICACY OF PRODUCT

(Tyr⁰)Fibrinopeptide A is a research and diagnostic calibrant/substrate, not a therapeutic. Its clinical "efficacy" lies in its critical role as a reference material in laboratory medicine. It is used to standardize and validate clinical assays that measure thrombin generation, fibrinopeptide A levels, or overall coagulation status. Accurate measurement of thrombin activity is essential for diagnosing hypercoagulable states, monitoring anticoagulant therapy (like heparin), and researching thrombotic diseases. Therefore, this peptide underpins the accuracy and reliability of tests that guide patient management in cardiovascular and hematological disorders.

4.DELIVERY & SHIPPING

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