(Tyr0)Fibrinopeptide A CAS NO.103226-11-5
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | (Tyr⁰)Fibrinopeptide A |
| CAS NO. | 103226-11-5 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₇₁H₉₉N₁₉O₂₁S |
| Molecular Weight | 1666.75 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water, dilute aqueous acetic acid, or DMSO |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Modulates platelet aggregation and fibrin formation; mimics the N-terminal extended form of fibrinopeptide A to study thrombin-mediated fibrinogen cleavage. |
| Storage Conditions | Store at -20°C to -80°C in a dry environment. Lyophilized powder is stable for 24 months at -20°C. Reconstituted solutions should be stored at -20°C and used within 3 months, avoiding repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide functions as a specific substrate for the serine protease thrombin. In the physiological coagulation cascade, thrombin cleaves native Fibrinopeptide A from the Aα chain of fibrinogen, initiating fibrin monomer polymerization. (Tyr⁰)Fibrinopeptide A mimics this natural cleavage site. The added tyrosine residue provides a convenient chromogenic or fluorogenic tag (when coupled to appropriate reporters) or improves detection in immunoassays. The rate of cleavage of this peptide by thrombin is directly proportional to the enzyme's activity, allowing for precise kinetic studies and quantification.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
(Tyr⁰)Fibrinopeptide A is a research and diagnostic calibrant/substrate, not a therapeutic. Its clinical "efficacy" lies in its critical role as a reference material in laboratory medicine. It is used to standardize and validate clinical assays that measure thrombin generation, fibrinopeptide A levels, or overall coagulation status. Accurate measurement of thrombin activity is essential for diagnosing hypercoagulable states, monitoring anticoagulant therapy (like heparin), and researching thrombotic diseases. Therefore, this peptide underpins the accuracy and reliability of tests that guide patient management in cardiovascular and hematological disorders.
4.DELIVERY & SHIPPING
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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
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