P55-TNFR

P55-TNFR is a purified, research-grade recombinant protein representing the soluble, extracellular ligand-binding domain of the human p55 (55 kDa) Tumor Necrosis Factor Receptor (also known as TNFR1, CD120a, or TNFRSF1A). This high-purity protein acts as a decoy receptor, specifically binding to its cognate ligands, Tumor Necrosis Factor-alpha (TNF-α) and Lymphotoxin-alpha (TNF-β), to neutralize their biological activity.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	P55-TNFR
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C₅₇H₉₅N₁₅O₂₂
Molecular Weight	1342.48 g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water, 0.1% TFA, or DMSO; reconstitute to 1-10 mg/mL
Endotoxin	≤1.0 EU/mg
Biological Activity	Binds to TNF-α with high affinity; inhibits TNF-α-mediated cytotoxicity (Inhibitory activity range: 0.1–1 μg/mL for fusion protein forms)
Storage Conditions	-20°C to -70°C (lyophilized); avoid repeated freeze-thaw cycles. Reconstituted solution: 4°C for 1-2 weeks, or -20°C for long-term storage with carrier protein.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

P55-TNFR functions as a competitive inhibitor in the TNF signaling pathway. It mimics the natural extracellular domain of the membrane-bound TNFR1 receptor. By binding with high affinity to soluble TNF-α and TNF-β, it sequesters these pro-inflammatory cytokines, preventing them from interacting with their endogenous cell-surface receptors (TNFR1 and TNFR2). This blockade inhibits the downstream activation of the NF-κB and MAPK signaling pathways, thereby suppressing the inflammatory, apoptotic, and immunomodulatory effects mediated by TNF.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in immunology, inflammation, and cell biology. Key applications include: as a specific TNF-α/TNF-β neutralizing agent to delineate the role of TNF in experimental models of inflammation (e.g., rheumatoid arthritis, sepsis, inflammatory bowel disease); as a control or tool to validate the specificity of TNF-mediated effects in cell-based assays (cytotoxicity, proliferation, cytokine production); in the study of TNF receptor signaling and shedding; and as a critical reagent for developing and standardizing TNF detection (ELISA) and neutralization assays.

3.CLINICAL EFFICACY OF PRODUCT

P55-TNFR itself is a research protein. Its clinical significance is profound as it served as the direct prototype for the development of successful biologic therapeutics. The knowledge gained from research with soluble TNFR constructs led directly to the creation of Etanercept, a fusion protein of the p75-TNFR extracellular domain and an IgG1 Fc fragment, which is a highly effective drug for treating autoimmune diseases like rheumatoid arthritis, psoriasis, and ankylosing spondylitis. Therefore, P55-TNFR is a foundational tool that validated TNF inhibition as a major therapeutic strategy.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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