Calcitonin, human CAS NO.21215-62-3
Calcitonin, human CAS NO.21215-62-3
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Calcitonin, human |
| CAS NO. | 21215-62-3 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C151H226N40O45S3 |
| Molecular Weight | 3417.87g /mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in 0.1 M acetic acid (≥ 1 mg/mL); slightly soluble in water; insoluble in organic solvents. |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Inhibits osteoclast-mediated bone resorption; lowers blood calcium and phosphate levels; has analgesic effects in bone pain conditions |
| Storage Conditions | Store at -20°C to -80°C in a sealed container, protected from light and moisture. After reconstitution, store at 2°C to 8°C for up to 7 days, or aliquot and freeze at -20°C for long-term use (avoid repeated freeze-thaw cycles). |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Calcitonin exerts its effects by binding to the Calcitonin Receptor (CTR), a G protein-coupled receptor, primarily on osteoclasts and renal tubular cells:
- Inhibition of Bone Resorption: In bone, it binds to receptors on osteoclasts, the cells responsible for breaking down bone. This binding inhibits osteoclast activity and motility, reducing bone resorption and the release of calcium and phosphate into the blood.
- Enhancement of Renal Calcium Excretion: In the kidneys, it acts on the distal tubules to inhibit calcium and phosphate reabsorption, increasing their excretion in the urine.
- Analgesic Effect: Calcitonin has a direct analgesic effect on the central nervous system, independent of its effects on calcium, which is beneficial in painful bone diseases like Paget's disease and osteoporosis.
2.PRODUCT INDICATIONS
- Bone Biology & Osteoporosis Research: Studying the regulation of osteoclast and osteoblast activity, bone remodeling, and the pathophysiology of metabolic bone diseases.
- Renal Physiology: Researching the hormonal control of calcium and phosphate handling in the kidneys.
- Receptor Pharmacology: As the definitive endogenous agonist for the Calcitonin Receptor (CTR) and the Amylin receptor, used to characterize receptor signaling and screen for receptor modulators.
- Pain Research: Investigating its central analgesic mechanisms in models of bone pain and neuropathic pain.
3.CLINICAL EFFICACY OF PRODUCT
- Therapeutic Efficacy for Paget's Disease: It is highly effective in reducing bone turnover, relieving bone pain, and promoting healing in Paget's disease of bone.
- Efficacy in Hypercalcemia: It provides a rapid, though often transient, reduction in serum calcium levels in hypercalcemic emergencies.
- Efficacy in Osteoporosis: It has been shown to increase bone mineral density and reduce the risk of vertebral fractures in postmenopausal osteoporosis. However, concerns about a potential increased risk of certain cancers and the availability of more potent agents (e.g., bisphosphonates, denosumab) have reduced its use for this indication.
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