Met-Enkephalin CAS NO.58569-55-4

Met-Enkephalin (Tyr-Gly-Gly-Phe-Met) is a naturally occurring pentapeptide and an endogenous opioid peptide. It is one of the two primary enkephalins, derived from the precursor protein proenkephalin, and acts as a neurotransmitter and neuromodulator in the central and peripheral nervous systems. It plays a key role in pain modulation, reward, mood, and stress responses. This high-purity synthetic peptide is an essential tool for neuroscience, pharmacology, and pain research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Met-Enkephalin
CAS NO.	58569-55-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C27H35N5O7S
Molecular Weight	573.67g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1–5 mg/mL), DMSO (≥23–40 mg/mL); also soluble in aqueous buffers and dilute acetic acid.
Endotoxin	< 1.0 EU/mg (Typical for research-grade peptides)
Biological Activity	Endogenous opioid peptide; potent agonist at mu (MOR), delta (DOR), and zeta-opioid receptors; exhibits analgesic, immunomodulatory, anti-inflammatory, and antinociceptive properties; regulates immune function and inhibits tumor growth via opioid receptor binding.
Storage Conditions	-20°C (1 year stability) or -80°C (2 years stability); desiccated, sealed, and protected from moisture/light; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Met-Enkephalin primarily exerts its effects by binding to and activating δ-opioid (DOP) and μ-opioid (MOP) receptors as an agonist. Its mechanism involves:

Receptor Activation: It binds with higher affinity to δ-opioid receptors, but also activates μ-opioid receptors.
G-protein Coupling: Receptor activation inhibits adenylate cyclase, reducing intracellular cAMP levels.
Ion Channel Modulation: It opens G-protein-coupled inwardly rectifying potassium (GIRK) channels, causing neuronal hyperpolarization, and inhibits voltage-gated calcium channels, reducing neurotransmitter release (e.g., glutamate, substance P).
Pain Signal Inhibition: This combined action suppresses the transmission of pain signals at spinal and supraspinal levels, producing analgesia.

2.PRODUCT INDICATIONS

This product is indicated for a wide range of in vitro and in vivo research applications, including:

Neuroscience & Pain Research: Investigating endogenous pain control systems, analgesia, and the pathophysiology of chronic pain.
Neuropharmacology: Studying opioid receptor function, signaling, and the effects of receptor agonists/antagonists.
Psychiatry & Addiction Research: Exploring its role in reward pathways, mood regulation, stress responses, and substance use disorders.
Immunology: Researching the interaction between the opioid and immune systems (e.g., on immune cell function).
Cell Signaling & Biochemistry: Used as a ligand in receptor binding assays and to study G-protein mediated signaling pathways.

3.CLINICAL EFFICACY OF PRODUCT

As an endogenous neuropeptide, Met-Enkephalin itself is not used as a direct therapeutic due to its rapid enzymatic degradation (by peptidases like NEP and ACE). However, its physiological role is fundamental, and strategies to enhance its activity are clinically relevant.

Validated Therapeutic Target: The enkephalinergic system is a major target for pain management. The clinical efficacy of targeting this pathway is demonstrated by opioid analgesics that act on the same receptors (MOP/DOP).
Enkephalinase Inhibitors: Drugs that inhibit the enzymes that degrade enkephalins (e.g., racecadotril) are used clinically for conditions like diarrhea, based on enhancing endogenous enkephalin activity in the gut.
Prototype for Drug Development: Met-Enkephalin serves as the lead structure for developing more stable, potent, and receptor-selective analgesic peptides, aiming for pain relief with fewer side effects than traditional opioids.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.