Met-Enkephalin CAS NO.58569-55-4
Met-Enkephalin CAS NO.58569-55-4
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Met-Enkephalin |
| CAS NO. | 58569-55-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C27H35N5O7S |
| Molecular Weight | 573.67g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥1–5 mg/mL), DMSO (≥23–40 mg/mL); also soluble in aqueous buffers and dilute acetic acid. |
| Endotoxin | < 1.0 EU/mg (Typical for research-grade peptides) |
| Biological Activity | Endogenous opioid peptide; potent agonist at mu (MOR), delta (DOR), and zeta-opioid receptors; exhibits analgesic, immunomodulatory, anti-inflammatory, and antinociceptive properties; regulates immune function and inhibits tumor growth via opioid receptor binding. |
| Storage Conditions | -20°C (1 year stability) or -80°C (2 years stability); desiccated, sealed, and protected from moisture/light; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Met-Enkephalin primarily exerts its effects by binding to and activating δ-opioid (DOP) and μ-opioid (MOP) receptors as an agonist. Its mechanism involves:
- Receptor Activation: It binds with higher affinity to δ-opioid receptors, but also activates μ-opioid receptors.
- G-protein Coupling: Receptor activation inhibits adenylate cyclase, reducing intracellular cAMP levels.
- Ion Channel Modulation: It opens G-protein-coupled inwardly rectifying potassium (GIRK) channels, causing neuronal hyperpolarization, and inhibits voltage-gated calcium channels, reducing neurotransmitter release (e.g., glutamate, substance P).
- Pain Signal Inhibition: This combined action suppresses the transmission of pain signals at spinal and supraspinal levels, producing analgesia.
2.PRODUCT INDICATIONS
This product is indicated for a wide range of in vitro and in vivo research applications, including:
- Neuroscience & Pain Research: Investigating endogenous pain control systems, analgesia, and the pathophysiology of chronic pain.
- Neuropharmacology: Studying opioid receptor function, signaling, and the effects of receptor agonists/antagonists.
- Psychiatry & Addiction Research: Exploring its role in reward pathways, mood regulation, stress responses, and substance use disorders.
- Immunology: Researching the interaction between the opioid and immune systems (e.g., on immune cell function).
- Cell Signaling & Biochemistry: Used as a ligand in receptor binding assays and to study G-protein mediated signaling pathways.
3.CLINICAL EFFICACY OF PRODUCT
As an endogenous neuropeptide, Met-Enkephalin itself is not used as a direct therapeutic due to its rapid enzymatic degradation (by peptidases like NEP and ACE). However, its physiological role is fundamental, and strategies to enhance its activity are clinically relevant.
- Validated Therapeutic Target: The enkephalinergic system is a major target for pain management. The clinical efficacy of targeting this pathway is demonstrated by opioid analgesics that act on the same receptors (MOP/DOP).
- Enkephalinase Inhibitors: Drugs that inhibit the enzymes that degrade enkephalins (e.g., racecadotril) are used clinically for conditions like diarrhea, based on enhancing endogenous enkephalin activity in the gut.
- Prototype for Drug Development: Met-Enkephalin serves as the lead structure for developing more stable, potent, and receptor-selective analgesic peptides, aiming for pain relief with fewer side effects than traditional opioids.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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