Dermorphin CAS NO.77614-16-5
Dermorphin CAS NO.77614-16-5
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Dermorphin |
| CAS NO. | 77614-16-5 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C40H50N8010 |
| Molecular Weight | 802.88g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water, dilute acetic acid and aqueous phosphate buffers |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | ≥90% relative potency (measured by μ-opioid receptor binding and activation assays). |
| Storage Conditions | Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Dermorphin exerts its effects as a highly selective and potent agonist of the μ-opioid receptor (MOR). Upon binding, it activates inhibitory G-proteins (Gi/Go), leading to the inhibition of adenylyl cyclase, reduced cAMP production, hyperpolarization of neurons via potassium efflux, and inhibition of calcium influx. This results in the inhibition of neurotransmitter release (like substance P) in pain pathways and activation of brainstem descending inhibitory pathways, producing powerful analgesia, euphoria, and respiratory depression characteristic of MOR agonism.
2.PRODUCT INDICATIONS
Neuroscience & Pharmacology Research: As a reference compound for studying μ-opioid receptor function, signaling, and ligand-receptor interactions.
Analgesic & Pain Research: Used in animal models to investigate potent analgesia, tolerance development, and opioid side effects.
Comparative Studies: For analyzing structure-activity relationships (SAR) of opioid peptides.
3.CLINICAL EFFICACY OF PRODUCT
Dermorphin is not approved for human therapeutic use. Preclinical animal studies demonstrate its extraordinary analgesic potency, estimated to be 30-40 times more potent than morphine following central administration. While its potency highlights the μ-receptor's role in pain modulation, its clinical development is hindered by significant side effects (severe respiratory depression, high addiction potential, rapid tolerance) and legal restrictions as a controlled substance analogue in many jurisdictions.
4.DELIVERY & SHIPPING
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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
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