Dermorphin CAS NO.77614-16-5
Dermorphin CAS NO.77614-16-5
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Dermorphin |
| CAS NO. | 77614-16-5 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C40H50N8010 |
| Molecular Weight | 802.88g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water, dilute acetic acid and aqueous phosphate buffers |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | ≥90% relative potency (measured by μ-opioid receptor binding and activation assays). |
| Storage Conditions | Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Dermorphin exerts its effects as a highly selective and potent agonist of the μ-opioid receptor (MOR). Upon binding, it activates inhibitory G-proteins (Gi/Go), leading to the inhibition of adenylyl cyclase, reduced cAMP production, hyperpolarization of neurons via potassium efflux, and inhibition of calcium influx. This results in the inhibition of neurotransmitter release (like substance P) in pain pathways and activation of brainstem descending inhibitory pathways, producing powerful analgesia, euphoria, and respiratory depression characteristic of MOR agonism.
2.PRODUCT INDICATIONS
Neuroscience & Pharmacology Research: As a reference compound for studying μ-opioid receptor function, signaling, and ligand-receptor interactions.
Analgesic & Pain Research: Used in animal models to investigate potent analgesia, tolerance development, and opioid side effects.
Comparative Studies: For analyzing structure-activity relationships (SAR) of opioid peptides.
3.CLINICAL EFFICACY OF PRODUCT
Dermorphin is not approved for human therapeutic use. Preclinical animal studies demonstrate its extraordinary analgesic potency, estimated to be 30-40 times more potent than morphine following central administration. While its potency highlights the μ-receptor's role in pain modulation, its clinical development is hindered by significant side effects (severe respiratory depression, high addiction potential, rapid tolerance) and legal restrictions as a controlled substance analogue in many jurisdictions.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Nov 05, 26
Global Market Analysis and Oxandrolone 50mg Price Guide
For B2B pharmaceutical buyers and researchers, understanding the oxandrolone 50mg price involves analyzing more than just a numerical value; it requires a comprehensive look at API purity, synthesis methods, and global supply chain stability. As a specialized anabolic steroid derivative, the cost is heavily influenced by the quality of raw materials and the rigor of the laboratory testing involved in the production process. This article explores the economic and technical variables that dictate market pricing for this specific compound. In the context of the global API market, pricing volatility is often tied to regulatory shifts in key manufacturing hubs
Nov 04, 26
How to Select High Purity Alisol C CAS 30489271 for Laboratory Research
High Purity Alisol C CAS 30489271 is suited to laboratories using Alisol C as a triterpenoid reference standard in metabolic, hepatology, pharmacology, HPLC/MS, botanical-extract, or selected cell-line research. We explain the application fit and the identity, purity, physical form, solvent, endotoxin, storage, quantity, and batch-record checks to make before ordering.
Nov 02, 26
Reliable Oxandrolone Supplier for High Purity Pharmaceutical APIs
When sourcing high-purity pharmaceutical ingredients for endocrine or cardiovascular research, the reliability of the supply chain is as critical as the chemical purity itself. For laboratories and manufacturers seeking a dependable oxandrolone supplier, the focus must extend beyond simple certificates of analysis to encompass consistent batch-to-batch stability and strict adherence to GMP standards. Whether the requirement is for small-scale pilot studies or large-scale industrial production, the ability to trace materials from raw synthesis to final lyophilized powder ensures the integrity of the resulting clinical or research data.