Isosinensetin CAS NO.17290-70-9

Isosinensetin CAS NO.17290-70-9

Isosinensetin CAS NO.17290-70-9

Isosinensetin CAS NO.17290-70-9

Isosinensetin CAS NO.17290-70-9

Isosinensetin is a naturally derived polymethoxyflavone predominantly sourced from citrus peels, especially those of sweet oranges and tangerines. Renowned for its exceptional lipophilicity and membrane permeability, this bioactive compound offers superior cellular absorption compared to more polar flavonoids, making it highly suitable for research in nutraceuticals, pharmaceuticals, and cosmetics. Its stable methoxylated structure ensures resilience under standard storage conditions, supporting consistent performance in formulations. With strong antioxidant, anti-inflammatory, and metabolic support properties, Isosinensetin is increasingly utilized in studies exploring cellular defense mechanisms, chronic disease mitigation, and healthy aging — positioning it as a valuable ingredient for scientists and formulators focused on functional health solutions.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Isosinensetin
CAS NO.
17290-70-9
Appearance
Off-white to pale yellow crystalline powder
Molecular Formula
C20H20O7
Molecular Weight
372.37 g/mol
Purity (RP-HPLC)
≥98.0%
Solubility

Soluble in DMSO, methanol, ethanol; slightly soluble in water

Endotoxin≤0.5 EU/mg (for biocompatible applications)
Biological Activity
Antioxidant, anti-inflammatory, neuroprotective, metabolic regulation
Storage Conditions
Store at 2–8°C, protected from light and moisture
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

Isosinensetin exerts its biological effects primarily through modulation of key signaling pathways involved in inflammation, oxidative stress, and metabolic regulation. It acts as an agonist for the human bitter taste receptor TAS2R50, triggering downstream Gβγ-mediated signaling that influences mitochondrial function, AMPK activation, and Nrf2 pathway upregulation — all critical for cellular protection and energy homeostasis. Additionally, its ability to scavenge reactive oxygen species (ROS) and inhibit pro-inflammatory mediators like NF-κB and COX-2 contributes to its neuroprotective and cardioprotective potential. These multi-target mechanisms make Isosinensetin a versatile modulator of cellular resilience, particularly relevant in age-related and stress-induced pathologies.

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2.PRODUCT INDICATIONS

Isosinensetin is indicated for use in preclinical and clinical research targeting inflammatory disorders, metabolic syndrome, neurodegenerative conditions, and oxidative stress-related diseases. Its applications extend to nutraceutical development for supporting cardiovascular health, cognitive function, and anti-aging regimens. Suitable for academic researchers, pharmaceutical R&D teams, and supplement formulators, this compound is particularly valuable in designing interventions aimed at enhancing cellular repair, reducing chronic inflammation, and improving mitochondrial efficiency. Its favorable pharmacokinetic profile and low toxicity in experimental models further support its use in both in vitro and in vivo studies seeking to validate its therapeutic potential.

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3.CLINICAL EFFICACY OF PRODUCT

Emerging clinical and preclinical data suggest that Isosinensetin exhibits significant efficacy in reducing markers of systemic inflammation, improving insulin sensitivity, and protecting against oxidative damage in tissue models. In animal studies, it has demonstrated protective effects against neurodegeneration, fatty liver disease, and endothelial dysfunction — often correlating with improved biomarkers such as TNF-α, IL-6, MDA, and SOD levels. While large-scale human trials are still underway, early findings support its role as a potent adjunct in managing metabolic and age-associated disorders. Its safety profile and bioactivity across multiple organ systems position Isosinensetin as a promising candidate for future therapeutic and functional food applications.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.


5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


Hot Tags: Isosinensetin, Polymethoxyflavone, CitrusExtract, Antioxidant, AntiInflammatory, MetabolicHealth,Neuroprotection, NutraceuticalIngredient, BioactiveCompound, ResearchChemical, HealthyAging, CellularDefense, Flavonoid, DietarySupplement, PharmaceuticalExcipient, Supplier, Manufacturer, Bulk order,  Pharmaceutical.


If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553

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