Sinapultide CAS NO.138531-07-4

Sinapultide is a surfactant protein mimetic and synthetic pulmonary surfactant developed for the treatment of respiratory distress syndrome (RDS) in preterm infants, consisting of the KL4 peptide designed to replicate the function of human surfactant protein B. This peptide-based therapeutic facilitates lung maturation and improves gas exchange by lowering surface tension in alveoli, offering a critical intervention for neonatal intensive care units to support premature infants with underdeveloped lungs.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Sinapultide
CAS NO.	138531-07-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₂₆H₂₃₈N₂₆O₂₂
Molecular Weight	2469.41g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Freely soluble in water and physiological saline; forms clear solutions upon reconstitution
Endotoxin	< 0.5 EU/mg (for pharmaceutical-grade material)
Biological Activity	Exhibits surfactant-like activity by reducing surface tension in lipid monolayers, mimicking human surfactant protein B; improves lung compliance and prevents atelectasis in vitro and in animal models
Storage Conditions	Store at 2–8°C in a dry, dark environment; protect from moisture and light; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Sinapultide functions by mimicking surfactant protein B, integrating into the phospholipid monolayer at the air-liquid interface in alveoli. The cationic KL4 peptide interacts with anionic phospholipids, promoting adsorption and spreading to form a stable film that dramatically reduces surface tension during expiration, preventing alveolar collapse and improving lung compliance and oxygenation in surfactant-deficient lungs.

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2.PRODUCT INDICATIONS

This product is indicated for the prevention and treatment of neonatal respiratory distress syndrome (RDS) in preterm infants, as well as for acute respiratory distress syndrome (ARDS) in adults. It is also utilized in research on meconium aspiration syndrome and other conditions characterized by surfactant dysfunction or deficiency, providing a synthetic alternative to animal-derived surfactants.

3.CLINICAL EFFICACY OF PRODUCT

Clinical trials have demonstrated that Sinapultide significantly improves oxygenation and reduces the need for mechanical ventilation in preterm infants with RDS, with outcomes comparable to animal-derived surfactants. It has shown efficacy in decreasing mortality and the incidence of bronchopulmonary dysplasia, establishing its role as a safe and effective synthetic surfactant in neonatal respiratory management.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Sinapultide #KL4Peptide #PulmonarySurfactant #NeonatalRDS #RespiratoryDistress #SyntheticSurfactant #PretermInfant #LungSurfactant

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