Bradykinin (1-7) CAS NO.23815-87-4

Bradykinin (1-7) is a high-purity, amino-terminally truncated heptapeptide (Arg-Pro-Pro-Gly-Phe-Ser-Pro) derived from the proteolytic cleavage of the parent vasoactive hormone Bradykinin, supplied as a stable lyophilized white to off-white powder for specialized biochemical and pharmacological research. As a key endogenous metabolite within the kallikrein-kinin system, this peptide serves as an essential reference standard and research tool for scientists investigating cardiovascular regulation, renal physiology, inflammatory signaling, and pain modulation pathways. Its well-defined sequence and specific biological properties make it indispensable for laboratories conducting enzyme kinetics, receptor binding studies, and preclinical assays aimed at understanding kinin peptide metabolism and developing novel therapeutics for hypertension, edema, and inflammatory disorders.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Bradykinin (1-7)
CAS NO.	23815-87-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C35H52N10O9
Molecular Weight	756.87 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Soluble in water or dilute acetic acid; insoluble in common organic solvents
Endotoxin	≤1.0 EU/mg
Biological Activity	Exhibits selective agonistic activity towards the B1 receptor; involved in anti-hypertensive effects, vasodilation, and modulation of inflammatory responses; inhibits cell proliferation and possesses antioxidant properties
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1.MECHANISM OF ACTION

The primary biological mechanism of Bradykinin (1-7) involves its role as a specific substrate and metabolite that interacts with the kininergic system, particularly influencing the activity and specificity of kininases and carboxypeptidases responsible for bradykinin degradation. Unlike its parent peptide, Bradykinin (1-7) exhibits reduced affinity for the classical B1 and B2 bradykinin receptors but plays a crucial role in the sequential metabolic processing of kinins, where it is further cleaved by carboxypeptidase M or N to produce shorter, inactive fragments like Bradykinin (1-5). This peptide can modulate cellular responses by competing with longer bradykinin fragments for enzymatic degradation pathways, thereby indirectly regulating the local availability and half-life of potent vasoactive kinins in tissues such as the kidney, heart, and vascular endothelium. Additionally, it may exert direct, albeit weaker, modulatory effects on nitric oxide synthesis and prostaglandin release in certain cellular contexts, contributing to the fine-tuning of vascular tone and inflammatory responses at the molecular signaling level without triggering the intense pro-inflammatory cascade associated with full-length Bradykinin.

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2.PRODUCT INDICATIONS

This product is specifically indicated for in vitro laboratory research, biochemical assay development, and analytical applications within pharmacological, physiological, and biochemical research settings focused on the kallikrein-kinin system and peptide metabolism. It serves as a primary external calibrant and standard for quantitative mass spectrometry (such as MALDI-TOF MS) and high-performance liquid chromatography (HPLC) analyses, enabling the accurate measurement and identification of kinin peptides in biological fluids and tissue homogenates. Researchers utilize Bradykinin (1-7) to evaluate the specificity, kinetics, and inhibitory potency of various kininases and peptidases, including angiotensin-converting enzyme (ACE) and neutral endopeptidase, in drug screening assays targeting these enzymatic pathways. Furthermore, it is indicated for cell-based studies examining kinin receptor desensitization, signal transduction differences between truncated and full-length kinins, and as a mechanistic tool for exploring the renal and cardiovascular effects of ACE inhibitor therapies, which are known to alter the tissue ratios of Bradykinin (1-7) to other kinin metabolites in preclinical models.

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3.CLINICAL EFFICACY OF PRODUCT

Although Bradykinin (1-7) is strictly designated for research use and is not a clinical therapeutic agent, extensive biochemical and preclinical studies have validated its significance as a stable metabolic marker and a critical component in the physiological regulation of the kallikrein-kinin system. Laboratory experiments confirm that Bradykinin (1-7) is reliably produced in vivo through the enzymatic action of endopeptidases on Bradykinin and accumulates in specific tissues, with renal concentrations documented at approximately 70 fmol/g of wet weight, establishing it as a major kinin metabolite alongside Bradykinin (1-9). Preclinical research utilizing ACE inhibitor treatments, such as perindopril, demonstrates that pharmacological intervention significantly alters the tissue distribution and metabolic ratios of kinin fragments, where the proportion of Bradykinin (1-7) relative to Bradykinin (1-9) decreases as upstream metabolites accumulate due to reduced degradation. These findings underscore the efficacy of Bradykinin (1-7) as a reliable research reagent for monitoring kinin system dynamics, validating peptidase assay conditions, and elucidating the complex interplay between kinin metabolism, blood pressure regulation, and the therapeutic effects of ACE modulation in cardiovascular and renal pathology models.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags:Bradykinin (1-7), Kinin Metabolite, Heptapeptide, Proteolytic Cleavage Product, Kallikrein-Kinin System, Vasoactive Peptide, Cardiovascular Research, Peptidase Substrate.

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