TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

The primary biological mechanism of Bradykinin (1-7) involves its role as a specific substrate and metabolite that interacts with the kininergic system, particularly influencing the activity and specificity of kininases and carboxypeptidases responsible for bradykinin degradation. Unlike its parent peptide, Bradykinin (1-7) exhibits reduced affinity for the classical B1 and B2 bradykinin receptors but plays a crucial role in the sequential metabolic processing of kinins, where it is further cleaved by carboxypeptidase M or N to produce shorter, inactive fragments like Bradykinin (1-5). This peptide can modulate cellular responses by competing with longer bradykinin fragments for enzymatic degradation pathways, thereby indirectly regulating the local availability and half-life of potent vasoactive kinins in tissues such as the kidney, heart, and vascular endothelium. Additionally, it may exert direct, albeit weaker, modulatory effects on nitric oxide synthesis and prostaglandin release in certain cellular contexts, contributing to the fine-tuning of vascular tone and inflammatory responses at the molecular signaling level without triggering the intense pro-inflammatory cascade associated with full-length Bradykinin.

2.PRODUCT INDICATIONS

This product is specifically indicated for in vitro laboratory research, biochemical assay development, and analytical applications within pharmacological, physiological, and biochemical research settings focused on the kallikrein-kinin system and peptide metabolism. It serves as a primary external calibrant and standard for quantitative mass spectrometry (such as MALDI-TOF MS) and high-performance liquid chromatography (HPLC) analyses, enabling the accurate measurement and identification of kinin peptides in biological fluids and tissue homogenates. Researchers utilize Bradykinin (1-7) to evaluate the specificity, kinetics, and inhibitory potency of various kininases and peptidases, including angiotensin-converting enzyme (ACE) and neutral endopeptidase, in drug screening assays targeting these enzymatic pathways. Furthermore, it is indicated for cell-based studies examining kinin receptor desensitization, signal transduction differences between truncated and full-length kinins, and as a mechanistic tool for exploring the renal and cardiovascular effects of ACE inhibitor therapies, which are known to alter the tissue ratios of Bradykinin (1-7) to other kinin metabolites in preclinical models.

3.CLINICAL EFFICACY OF PRODUCT

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags:Bradykinin (1-7), Kinin Metabolite, Heptapeptide, Proteolytic Cleavage Product, Kallikrein-Kinin System, Vasoactive Peptide, Cardiovascular Research, Peptidase Substrate.

If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85294920037