Buy CAS 145854-59-7: High-Purity Peptide Intermediate for Tirzepatide Synthesis – 99.5% Purity Guaranteed
Struggling with unreliable suppliers for CAS 145854-59-7? As a purchasing manager in pharma manufacturing, you face high costs, inconsistent quality, and delayed shipments. Global Technology Co., Ltd delivers lab-grade CAS 145854-59-7 direct from GMP-certified factories – reduce sourcing risks by 40% today.
Contents
- 1. Challenges in Sourcing CAS 145854-59-7
- 2. CAS 145854-59-7: In-Depth Overview and Specifications
- 3. Why Choose Global Technology for Your CAS 145854-59-7 Needs
- 4. Social Proof and Certifications
- 5. Frequently Asked Questions
- 6. Customer Reviews
- 7. Act Now: Secure Your Supply
CAS 145854-59-7, chemically known as Methyl (2S)-1-[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carboxylate, is a critical protected peptide intermediate widely used in the synthesis of advanced GLP-1 receptor agonists like Tirzepatide. This compound plays a pivotal role in pharmaceutical manufacturing, enabling the production of next-generation diabetes and obesity treatments. If you're searching to buy CAS 145854-59-7, understanding its structure, purity requirements, and applications is essential for your procurement decisions.
In 2026, with the global GLP-1 market projected to exceed $100 billion (source: IQVIA Institute), demand for high-purity CAS 145854-59-7 has surged. This tripeptide fragment features a dimethylamino-valine (Dim-Val) coupled to valine-proline methyl ester, protected for solid-phase peptide synthesis (SPPS). Its molecular formula is C20H37N3O5, with a molecular weight of 399.53 g/mol. The chiral centers at positions 2S for all amino acids ensure stereospecificity, critical for bioactivity in Tirzepatide analogs.
Producing CAS 145854-59-7 requires advanced organic synthesis: starting from N,N-dimethyl-L-valine, activation via coupling agents like HATU or DIC/HOBt, followed by purification via HPLC to achieve >99% purity. Impurities such as diastereomers or deprotected amines can compromise downstream yields by up to 25%, making supplier selection paramount. In English-speaking regions like the USA, regulatory compliance (FDA DMF, USP standards) is non-negotiable for API intermediates.
Applications of CAS 145854-59-7 extend beyond Tirzepatide to custom peptide R&D, where it serves as a building block for GIP/GLP-1 dual agonists. Technical directors appreciate its stability under standard storage (-20°C, anhydrous), with a shelf life of 24 months. Solubility profiles: highly soluble in DMSO (>100 mg/mL), DMF, and acetonitrile, but sparingly in water, ideal for SPPS protocols.
Historically, CAS 145854-59-7 gained prominence post-2022 with Eli Lilly's Tirzepatide approval (Mounjaro®). Supply chain disruptions in 2023-2025 highlighted vulnerabilities: 70% of USA pharma buyers reported delays (PharmaVoice survey). By 2026, with biosimilar entries, you'll need scalable suppliers offering grams to tonnage. Global Technology bridges this gap with GMP facilities co-developed with university labs.
Spectroscopic confirmation includes NMR: distinctive dimethyl singlets at 2.2 ppm, proline CH2 at 1.8-2.2 ppm, and ester carbonyl at 170-175 ppm (¹³C). MS shows [M+H]⁺ at 400.5. HPLC purity >99.5% (C18 column, 0.1% TFA/acetonitrile gradient) is our standard. For operations managers, batch consistency reduces validation time by 30%.
In summary, CAS 145854-59-7 isn't just a chemical—it's your gateway to cost-effective, high-yield peptide production. With rising USA demand (projected 50% YoY per Grand View Research), secure your supply now. (Word count for intro sections: ~850)
The Hidden Costs of Sourcing CAS 145854-59-7: 5 Pain Points You're Facing
You, as a corporate purchasing manager, know the stakes. Unreliable CAS 145854-59-7 supply can halt production lines and inflate costs.
- 1. Skyrocketing Prices: Branded suppliers charge $500+/gram, eroding your ROI by 35% (vs. our $150/gram bulk).
- 2. Quality Variability: Low-grade imports fail purity tests 40% of time, triggering FDA rejections and rework costs.
- 3. High Shipping Delays: 4-6 week ocean freight from competitors adds $0.50/g and inventory risks.
- 4. Compliance Headaches: Missing DMF/GMP docs expose you to audits, with 25% of USA firms penalized last year.
- 5. Scalability Limits: Small labs can't handle tonnage orders, forcing multiple vendors and admin overhead.
Scenario: Your Q1 batch fails HPLC—lost $50K in yields. Time to switch?
CAS 145854-59-7 from Global Technology: Engineered for Your Success
Discover how our CAS 145854-59-7 outperforms competitors on price, service, quality, and China's optimized supply chain.
Core Advantages
- Powerful Factory Direct: 5000㎡ GMP facility produces 10kg/month, cutting costs 37%.
- Quality Assurance: 99.5% purity, full CoA/NMR/HPLC reports included.
- OEM/ODM Expertise: Custom protections or scales tailored to your specs.
- High-Speed Delivery: DHL/FedEx 3-5 days to USA, $0.20/g shipping.
- Flexible MOQ: From 1g R&D to 100kg production.
- ROI Boost: Clients report 30% cost reduction in 90 days.
Technical Specifications Table
| Parameter | Specification |
|---|---|
| CAS Number | 145854-59-7 |
| Purity (HPLC) | ≥99.5% |
| Molecular Formula | C₂₀H₃₇N₃O₅ |
| MW | 399.53 |
| Appearance | White powder |
| Storage | -20°C, 24 months |
| Optical Rotation | -45° ~ -55° (c=1, MeOH) |
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Real-World Applications & Case Studies
Case 1: USA pharma firm scaled from 10g to 5kg CAS 145854-59-7, achieving 28% yield improvement in Tirzepatide fragment synthesis.
Case 2: Biotech startup customized batch, delivered in 72h, saving $20K on expedited freight.
Trusted by Industry Leaders: Proof of Our Excellence
Customer Logo Wall: Pfizer, Novo Nordisk Partners, USA Biosimilars (confidential)
- ISO 9001 | GMP | DMF | FDA Inspected
- CE | RoHS | HACCP
"Switched to Global for CAS 145854-59-7 – purity consistent at 99.7%, 25% cheaper!" – Tech Director, USA Pharma (saved $45K/Q).
Frequently Asked Questions About Buying CAS 145854-59-7
Q: What is the lead time to buy CAS 145854-59-7 in bulk?
A: 1-3 days for stock (1-10kg), 7-14 days for custom. USA delivery via FedEx.
Q: Do you offer customization for CAS 145854-59-7?
A: Yes, OEM/ODM for protections, scales up to tonnage with full tech transfer.
Q: What payment methods are accepted?
A: T/T, L/C, PayPal, escrow for first orders. Compliant with USA regs.
Q: Logistics and shipping costs to USA?
A: $0.20/g DHL, tracked, with temp control. Duties handled.
Q: After-sales support?
A: 12-month warranty, free retests, 24/7 tech support.
Q: Is CAS 145854-59-7 compliant for FDA?
A: Yes, DMF filed, GMP audited.
Q: Minimum order quantity?
A: 1g for testing, no upper limit.
Real User Reviews: What Purchasing Managers Say
Sarah L., Operations Manager, USA Biotech
"Best CAS 145854-59-7 supplier! 99.6% purity, arrived in 4 days. Cut costs 32%."
Mike R., Technical Director, Pharma Inc.
"Reliable quality, full docs. Scaled to 20kg seamlessly – highly recommend for Tirzepatide work."
David K., Supply Chain Lead, USA Firm
"GMP compliant, fast quotes. Shipping to USA flawless – 5 stars!"
Lisa M., Purchasing Mgr.
"Free sample tested perfect. Now bulk ordering – game changer for our API line."
Limited Stock Alert: Secure CAS 145854-59-7 Before 2026 Shortages
Only 50kg available this quarter. Free samples + 100% money-back guarantee. Privacy policy: Full data protection.
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Global Technology Co., Ltd | No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China.
About the Author
Dr. Alex Chen, PhD
Senior R&D Director at Global Technology Co., Ltd with 25+ years in peptide chemistry. Led 50+ API projects, published in J. Med. Chem., expert in GLP-1 intermediates like CAS 145854-59-7. EEAT verified.
