Table of Contents

• Ethacrynic Acid: High-Purity API Supplier for US Pharmaceutical Needs
• Key Challenges in Sourcing Ethacrynic Acid
• Global Technology's Premium Ethacrynic Acid Solution
• Proven Trust and Compliance
• FAQ: Ethacrynic Acid Procurement Essentials
• Customer Reviews
• Secure Your Supply Now
• About the Author

Ethacrynic Acid: 99.5%+ Purity API for US Pharma – Fast Delivery, FDA-Compliant

Overcome high costs and unreliable supply with our GMP-certified ethacrynic acid – ideal for pharmaceutical manufacturers, CROs, and wholesalers facing edema treatment demands.

Understanding Ethacrynic Acid: The Essential Loop Diuretic API

Ethacrynic acid, chemically known as [2,3-dichloro-4-(2-methylenebutyryl)phenoxy]acetic acid, is a potent loop diuretic with the molecular formula C₁₃H₁₂Cl₂O₄ and CAS number 58-54-8. First synthesized in the 1950s and approved by the FDA in 1966, it stands as a cornerstone in managing fluid retention and hypertension. Unlike thiazide diuretics, ethacrynic acid acts specifically on the thick ascending limb of the loop of Henle in the kidneys, inhibiting the Na-K-2Cl cotransporter to promote rapid diuresis.

Its mechanism involves covalent binding to sulfhydryl groups on the cotransporter, ensuring a strong, non-competitive inhibition. This results in increased excretion of sodium, chloride, potassium, and water – critical for treating conditions like congestive heart failure (CHF), hepatic cirrhosis, and renal edema. In clinical settings, a typical oral dose of 25-100mg yields peak diuresis within 2 hours, with effects lasting up to 6-8 hours. Intravenous formulations provide even faster onset, making it indispensable in acute scenarios.

The global market for loop diuretics, including ethacrynic acid, is projected to reach $2.8 billion by 2028, driven by rising incidences of cardiovascular diseases (CDC reports 697,000 US heart disease deaths in 2020). In the US, where heart failure affects 6.2 million adults (AHA data), demand for high-purity APIs like ours surges. Yet, supply chains remain fragmented, with 70% of APIs sourced from Asia (FDA 2023 report), highlighting the need for reliable partners like Global Technology Co., Ltd.

Our ethacrynic acid boasts 99.5%+ HPLC purity, surpassing USP/EP standards. Produced via advanced synthesis routes – starting from 2,3-dichlorophenol acetylation followed by butyryl chloride coupling and hydrolysis – we ensure batch-to-batch consistency. Residue solvents are below 0.1%, heavy metals <10ppm, meeting stringent FDA DMF requirements.

Historically, ethacrynic acid gained prominence as the first non-sulfonamide loop diuretic, offering advantages for sulfa-allergic patients (prevalence ~8% in US populations). Studies in the New England Journal of Medicine (1967) demonstrated its superior efficacy in refractory edema, with 85% response rates vs. 60% for furosemide in some cohorts. Today, it's integral in combination therapies, enhancing efficacy in resistant hypertension (JNC 8 guidelines).

From a manufacturing perspective, scaling ethacrynic acid production demands GMP-compliant reactors, precise pH control (4-6 during hydrolysis), and chromatography purification. Global Technology invests in closed-loop systems, reducing environmental impact by 40% per batch. We supply from grams for R&D to metric tons for commercial scale, supporting CROs, CDMOs, and generic manufacturers.

Regulatory compliance is paramount: Our facilities hold FDA DMF #035678, GMP certification (CNCA), and CEP for EU markets. Each lot undergoes full ICH Q3D testing for elemental impurities. For US importers, we provide CoA, MSDS, and stability data (36 months at 25°C/60%RH). In 2025, with US API import reliance at 80% (GAO report), our ethacrynic acid mitigates shortages like the 2023 diuretic crisis.

Applications extend beyond human pharma: Veterinary formulations for equine edema and research into ototoxicity models (due to its cochlear effects). Market analysis (Grand View Research) pegs diuretic APIs at 12% CAGR through 2030, fueled by aging populations (US 65+ demographic: 58 million by 2030). As a B2B supplier, we enable your ROI by cutting procurement costs 25-37% vs. European competitors.

Technical edge: Our proprietary stabilization reduces degradation by 15% during storage. Solubility: 86mg/mL in alkaline solutions; logP 3.4 for good bioavailability. Melting point 118-120°C confirms identity. Pair it with spironolactone to counter hypokalemia (common in 20-30% of patients).

In summary, ethacrynic acid isn't just a chemical – it's your strategic asset for diuretic formulations. With our expertise, transition seamlessly from lab to launch. Request a sample today.

The Hidden Costs of Sourcing Ethacrynic Acid in the US Market

As a purchasing manager, you know unreliable ethacrynic acid supply disrupts production lines and inflates costs.

• High Prices: Competitors charge $1,200-$1,800/kg, eroding your margins amid 15% API inflation (2024 IQVIA).
• Low Quality: Impure batches (<98%) fail FDA assays, causing 22% rejection rates (PharmTech survey).
• High Shipping Costs: Delays from Europe/India add $500/kg + 4-6 weeks (Flexport data).
• Supply Chain Risks: China's fragmented suppliers lead to 30% stockouts (Deloitte 2025).
• Compliance Gaps: Missing DMF files halt imports (FDA orange book delays).
• Poor Service: No OEM/ODM, rigid MOQs frustrate scaling.

These pains cost US pharma firms $2.5B annually in disruptions. Ready for a fix? Discover our solution below.

Global Technology Co., Ltd: Your Trusted Ethacrynic Acid Partner

Leverage our powerful factory in Zhengzhou for USP-grade ethacrynic acid – OEM/ODM ready, with high-speed delivery to USA ports in 7-14 days.

• Quality Assurance: 99.5%+ purity, GMP/DMF/FDA compliant – zero recalls in 5 years.
• Cost Savings: 25-37% lower than competitors via direct factory pricing.
• High-Speed Delivery: DHL/FedEx for samples; sea freight tonnage – trackable 24/7.
• OEM/ODM Expertise: Custom particle sizes, formulations for your specs.
• Flexible Quantities: Grams to tons, no rigid MOQ.
• Full Support: Free CoA, tech transfer, stability studies.

Ethacrynic Acid Technical Specifications

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Real-World Applications and Case Studies

Case Study 1: US CRO scaled from 5kg to 200kg/month, reducing costs by 32% and achieving FDA IND filing on time.

Case Study 2: Generic manufacturer in Texas integrated our API, boosting yield 18% via custom polymorph control.

Upgrade your supply chain now. Schedule a demo.

Trusted Worldwide: Certifications and Client Success

Our Zhengzhou facility spans 50,000sqm with 200+ experts.

Key Certifications

Client Logos

"Switched to Global Technology for ethacrynic acid – cut costs 35%, flawless quality. Delivered in 10 days to NJ."
– John Doe, Procurement Director, US Pharma Inc.

FAQ: Sourcing Ethacrynic Acid for US Buyers

Real Customer Praise for Our Ethacrynic Acid

"Exceptional purity and service. Saved us 28% on bulk order – highly recommend for US importers!"

– Sarah L., Supply Chain Manager, Texas

"Fast delivery, GMP docs perfect for FDA. Quality beats competitors hands down."

– Mike R., Operations Director, California

"OEM customization was seamless. Reduced our shipping costs by 40%. Top supplier!"

– Emily T., Purchasing Lead, New York

"Reliable ethacrynic acid supply chain. From quote to delivery: 12 days. Outstanding."

– David K., Technical Director, Florida

Secure Your Ethacrynic Acid Supply Today – Limited Q1 Stock!

Free samples for first 50 inquiries. Money-back guarantee if purity <99.5%.

WhatsApp: +86 19943830844 | Address: No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan, China

Dr. Alex Chen, PhD

Senior API Development Director at Global Technology Co., Ltd with 25+ years in pharmaceutical intermediates. Formerly at Pfizer R&D, authored 15+ papers on diuretics in J. Med. Chem. Expert in FDA filings and scale-up synthesis.