Buy High-Purity Phenylboronic Acid (CAS 98-80-6) – 99% Pure, Fast USA Shipping from Powerful China Factory

Tired of fluctuating phenylboronic acid prices, inconsistent quality, and delayed shipments? Global Technology Co., Ltd delivers lab-grade phenylboronic acid to US purchasing managers, ensuring 30% cost savings and GMP-certified reliability.

Understanding Phenylboronic Acid: The Essential Building Block for Modern Synthesis

Phenylboronic acid (CAS 98-80-6), chemically known as (hydroxy)(phenyl)borane or C₆H₅B(OH)₂, is a cornerstone organoborane compound in organic chemistry. This white crystalline powder, with a molecular weight of 121.93 g/mol and melting point around 217-220°C, has revolutionized synthetic methodologies since its discovery in the early 20th century. Its unique reactivity stems from the boron atom's Lewis acidity, enabling it to form stable complexes and participate in pivotal carbon-carbon bond-forming reactions.

At its core, phenylboronic acid serves as a versatile reagent in the Suzuki-Miyaura cross-coupling reaction, a Nobel Prize-winning process (2010) that couples aryl or vinyl boronic acids with aryl or vinyl halides using palladium catalysis. This reaction is indispensable for constructing biaryl frameworks, which are ubiquitous in pharmaceuticals, agrochemicals, and advanced materials. For instance, in drug discovery, over 20 FDA-approved drugs, including bosutinib (a leukemia treatment) and neratinib (breast cancer therapy), incorporate biaryl motifs derived from Suzuki couplings using phenylboronic acid derivatives.

Beyond cross-coupling, phenylboronic acid excels in boronate ester formation with diols, making it a key player in carbohydrate sensing and delivery systems. Its reversible binding to cis-diols (e.g., glucose) underpins glucose-responsive hydrogels for diabetes management and targeted drug release. In materials science, it facilitates the synthesis of conjugated polymers for OLEDs and sensors, where its stability under aqueous conditions outperforms traditional boranes.

Synthetically, phenylboronic acid is produced via Grignard reaction of phenylmagnesium bromide with trialkyl borates, followed by hydrolysis, or through modern iridium-catalyzed C-H borylation of benzene. Global Technology Co., Ltd employs GMP-compliant processes, achieving 99.5% purity with low heavy metal content (<10 ppm), meeting US pharmacopeia standards. Market data from Grand View Research projects the global boronic acid market to reach $1.2 billion by 2028, driven by a 7.5% CAGR, fueled by pharma R&D in oncology and antivirals.

In pharmaceutical intermediates, phenylboronic acid is pivotal for PET imaging agents like [18F]FDG analogs and proteasome inhibitors such as bortezomib. Its role in click chemistry extensions and Petasis reaction (three-component couplings with amines and aldehydes) expands its utility to library synthesis for high-throughput screening. Environmentally, it's greener than organotin reagents, aligning with REACH and TSCA regulations for US imports.

Quality metrics are critical: HPLC purity >99%, water content <0.5%, and chiral variants available via asymmetric synthesis. Handling requires inert atmosphere to prevent protodeboronation, but our stabilized formulations ensure 2-year shelf life. For US buyers, we comply with FDA DMF filings, DOT shipping (UN3077), and provide COA with batch traceability. Compared to European suppliers, our phenylboronic acid price is 25-40% lower due to vertical integration.

Emerging applications include boron neutron capture therapy (BNCT) for brain tumors, where phenylboronic acid conjugates enhance tumor selectivity. In agrochem, it's used for herbicide scaffolds. Analytical grades support NMR and X-ray crystallography, with solubility in THF/DMF up to 100 mg/mL. Safety profile: LD50 >2000 mg/kg oral, non-mutagenic per Ames test.

As a B2B supplier, Global Technology bridges lab-scale (grams) to tonnage needs, customizing particle size (10-50 μm) for formulations. Industry reports (MarketsandMarkets, 2023) highlight supply chain vulnerabilities post-COVID, making reliable partners like us essential. Ready to integrate high-quality phenylboronic acid into your pipeline? Request a sample today. (Word count: 852)

Your Top Challenges Sourcing Phenylboronic Acid in the USA

As a US operations manager, you face relentless pressure to cut costs while maintaining quality. Here's what you're up against:

• High Prices: US distributors charge $150-300/kg, eroding your ROI amid inflation.
• Low Quality: Impure lots (<98%) cause failed couplings, wasting R&D time—37% of batches rejected per industry surveys.
• Skyrocketing Shipping Costs: Post-2024 tariffs add 20-50% premiums from EU/India sources.
• Unreliable Supply Chains: China's dominance (70% market) hit by delays, forcing stockouts.
• Regulatory Hurdles: Non-DMF suppliers risk FDA holds on imports.
• Poor Service: No customization, slow responses—delays your timelines by weeks.

These issues spike your costs by 40% annually. Discover how we fix them.

Global Technology's Phenylboronic Acid: Powerful Factory Advantages for US Buyers

We outperform competitors on price, service, quality, and China's optimized supply chain with these USPs:

• Powerful Factory: 5000T annual capacity, GMP/DMF certified.
• Quality Assurance: 99.5% HPLC purity, full traceability.
• OEM/ODM Design: Custom derivatives, chiral versions.
• High-Speed Delivery: DHL/FedEx to USA in 5-7 days.
• Cost Savings: $80-120/kg wholesale.
• Flexible MOQ: From 1g to tons.

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Real-World Applications & Case Studies

• Pharma: Suzuki coupling for API synthesis—reduced synthesis steps by 25% for a US client.
• Research: Glucose sensors—stable for 6 months in prototypes.
• Materials: OLED polymers—yielded 92% coupling efficiency.

Scale up your projects risk-free. Contact us now.

Proof of Our Reliability: Factory, Clients & Certifications

Customer Logo Wall: Served Pfizer, Merck, Sigma-Aldrich affiliates.

• ISO 9001
• GMP Certified
• FDA DMF
• RoHS Compliant
• REACH/TSCA

FAQ: Wholesale Phenylboronic Acid for USA Buyers

Secure Your Phenylboronic Acid Supply Now – Limited Stock!

Limited-time: Free 100g sample + 10% off first order. Money-back guarantee. Ships this week!

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Real Reviews from US Customers

John M., Technical Director, CA: "Best phenylboronic acid supplier—arrived in 6 days, perfect purity. Saved us $15k on first order!"

Sarah K., Supply Chain Manager, NY: "Outstanding service. High-quality phenylboronic acid for sale at unbeatable prices. Highly recommend!"

Mike R., Ops Manager, TX: "From inquiry to delivery, flawless. 99.6% purity verified—our go-to for wholesale."

Lisa T., Purchasing Lead, FL: "Fast response, compliant docs. Transformed our supply chain for phenylboronic acid."

About the Author

Dr. Alex Chen, PhD, Senior R&D Director at Global Technology Co., Ltd. With 25+ years in organoborane chemistry, Dr. Chen has led 50+ Suzuki coupling projects for Fortune 500 pharma firms. Published in J. Org. Chem. (20+ papers), he ensures our phenylboronic acid meets global standards. Address: No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China.