β‑MSH, porcine CAS NO.19941-13-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | β‑MSH, porcine |
| CAS NO. | 19941-13-0 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₉₈H₁₃₈N₂₆O₂₉S |
| Molecular Weight | 2176.4g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥1 mg/mL), PBS (pH 7.2–7.4), and DMSO; slightly soluble in ethanol |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Agonist at melanocortin receptors (MC1R, MC3R, MC4R, MC5R); stimulates melanin synthesis; modulates appetite and energy metabolism; anti‑inflammatory activity |
| Storage Conditions | -20°C for long‑term storage (stable for 2 years); avoid repeated freeze‑thaw; store desiccated |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The biological effects of β‑MSH, porcine are primarily mediated through its high-affinity binding to melanocortin receptors (MCRs), a family of G-protein-coupled receptors distributed across various tissues. In melanocytes, binding to MC1R activates the cAMP/PKA signaling pathway, which phosphorylates the microphthalmia-associated transcription factor (MITF). Phosphorylated MITF upregulates the expression of tyrosinase and other melanin-synthesis-related enzymes, thereby promoting melanin production and skin pigmentation.
2.PRODUCT INDICATIONS
Skin pigmentation research: Investigation of melanin synthesis mechanisms, development of tools for studying hypopigmentation and hyperpigmentation disorders.
Metabolic research: Exploration of appetite regulation pathways and potential therapeutic targets for obesity, diabetes, and metabolic syndrome.
Anti-inflammatory research: Development of novel anti-inflammatory agents for treating neuroinflammation, autoimmune diseases, and inflammatory skin conditions.
3.CLINICAL EFFICACY OF PRODUCT
β‑MSH, porcine is currently in preclinical research stages, with promising efficacy demonstrated in multiple in vitro and in vivo models. In animal studies, it has shown significant ability to stimulate melanin synthesis in porcine and rodent melanocytes, providing a potential research basis for treating hypopigmentation disorders such as vitiligo.
4.DELIVERY & SHIPPING
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Shipping Methods
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