β-Elemene CAS NO.515-13-9
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | β-Elemene |
| CAS NO. | 515-13-9 |
| Appearance | Colorless to pale yellow clear liquid |
| Molecular Formula | C₁₅H₂₄ |
| Molecular Weight | 204.35 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in DMF, DMSO, ethanol, chloroform, ether, and petroleum ether; practically insoluble in water Soluble in ethanol:PBS (pH 7.2) (1:2) at 0.3 mg/mL |
| Endotoxin | < 1.0 EU/mg |
| Storage Conditions | 2–8°C, tightly sealed, protected from light and air; avoid prolonged exposure to high temperatures |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
β-Elemene exerts its antitumor effects through multiple, non-overlapping pathways that induce cell cycle arrest and apoptosis. It downregulates oncogenes (e.g., Bcl-2, Survivin) and upregulates tumor suppressors (e.g., p53, Bax). A key mechanism involves the inhibition of the STAT3 signaling pathway, disrupting cancer cell proliferation and survival. It also induces apoptosis via the mitochondrial pathway (caspase-3/9 activation), promotes autophagy, inhibits tumor angiogenesis by suppressing VEGF, and reverses multidrug resistance (MDR) by downregulating P-glycoprotein expression. Its anti-inflammatory action via NF-κB inhibition contributes to its overall therapeutic profile.
2.PRODUCT INDICATIONS
- Oncology Research: Investigation of antitumor mechanisms, chemosensitization, and radiosensitization in lung, liver, brain, ovarian, and hematological cancers.
- Pharmaceutical Development: Reference standard for the quality control of β-Elemene injections, emulsions, and related herbal extracts.
- Pharmacology Studies: Exploration of anti-metastatic, anti-angiogenic, and multidrug resistance reversal properties.
- Anti-inflammatory Research: Study of effects on macrophage polarization and cytokine production in tumor microenvironments.
3.CLINICAL EFFICACY OF PRODUCT
Extensive clinical data from China supports the efficacy and safety of β-Elemene. As an adjunct therapy, it improves quality of life, reduces malignant effusions (pleural, peritoneal), and enhances the efficacy of radiotherapy and chemotherapy for non-small cell lung cancer, gliomas, and liver cancer. It demonstrates a favorable safety profile with minimal myelosuppression. Meta-analyses of clinical trials confirm its benefits in increasing tumor response rates and stabilizing disease, validating its role as a well-tolerated, multi-target natural anticancer agent.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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